Effects of green tea on serum paraoxonase/arylesterase activities in streptozotocin-induced diabetic rats

被引:27
作者
Tas, S [1 ]
Sarandol, E
Ziyanok, S
Aslan, K
Dirican, M
机构
[1] Uludag Univ Sci & Literature Fac, Dept Biol, TR-16059 Bursa, Turkey
[2] Uludag Univ, Fac Med, Dept Biochem, TR-16059 Bursa, Turkey
关键词
rat; diabetes; streptozotocin; green tea; oxidative stress; paraoxonase;
D O I
10.1016/j.nutres.2005.10.001
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
In recent years, green tea has become a subject of interest because of its beneficial effects on human health. The purpose of this study was to determine the effects of green tea on serum paraoxonase/arylesterase activities and lipoprotein oxidizability in streptozotocin-induced diabetic rats (65 mg/kg [intraperitoneal]). Green tea was given in tap water (2%) for 3 and 6 weeks to control (CGT-3w and CGT-6w) and diabetic (DGT-3w and DGT-6w) rats, and they were compared with the control and diabetic groups (D-3w and D-6w), respectively. Serum insulin level was significantly increased in the DGT-6w group; serum lipid and plasma and tissue malondialdehyde levels were reduced in the DGT-3w and DGT-6w groups. Oxidizability of apolipoprotein B-containing lipoprotein fraction was found to be significantly reduced in the DGT-6w group. Serum total antioxidant capacity showed a significant increase in the CGT-6w and DGT-6w groups. Paraoxonase activity was significantly reduced in the D-3w and D-6w groups and increased in the DGT-6w group. We conclude that green tea might have antilryperlipidernic and antioxidative effects and may slow the progression of atherogenesis by reducing oxidation of lipoproteins and preserving paraoxonase activity. (c) 2005 Elsevier Inc. All rights reserved.
引用
收藏
页码:1061 / 1074
页数:14
相关论文
共 42 条
[1]   SERUM PARAOXONASE ACTIVITY, CONCENTRATION, AND PHENOTYPE DISTRIBUTION IN DIABETES-MELLITUS AND ITS RELATIONSHIP TO SERUM-LIPIDS AND LIPOPROTEINS [J].
ABBOTT, CA ;
MACKNESS, MI ;
KUMAR, S ;
BOULTON, AJ ;
DURRINGTON, PN .
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 1995, 15 (11) :1812-1818
[2]   INSULIN-LIKE ACTIVITY IN (-) EPICATECHIN [J].
AHMAD, F ;
KHALID, P ;
KHAN, MM ;
RASTOGI, AK ;
KIDWAI, JR .
ACTA DIABETOLOGICA LATINA, 1989, 26 (04) :291-300
[3]   Pomegranate juice consumption for 3 years by patients with carotid artery stenosis reduces common carotid intima-media thickness, blood pressure and LDL oxidation [J].
Aviram, M ;
Rosenblat, M ;
Gaitini, D ;
Nitecki, S ;
Hoffman, A ;
Dornfeld, L ;
Volkova, N ;
Presser, D ;
Attias, J ;
Liker, H ;
Hayek, T .
CLINICAL NUTRITION, 2004, 23 (03) :423-433
[4]   Human serum paraoxonase (PON 1) is inactivated by oxidized low density lipoprotein and preserved by antioxidants [J].
Aviram, M ;
Rosenblat, M ;
Billecke, S ;
Erogul, J ;
Sorenson, R ;
Bisgaier, CL ;
Newton, RS ;
La Du, B .
FREE RADICAL BIOLOGY AND MEDICINE, 1999, 26 (7-8) :892-904
[5]   Paraoxonase inhibits high-density lipoprotein oxidation and preserves its functions - A possible peroxidative role for paraoxonase [J].
Aviram, M ;
Rosenblat, M ;
Bisgaier, CL ;
Newton, RS ;
Primo-Parmo, SL ;
La Du, BN .
JOURNAL OF CLINICAL INVESTIGATION, 1998, 101 (08) :1581-1590
[6]   Serum paraoxonase is reduced in type 1 diabetic patients compared to non-diabetic, first degree relatives; influence on the ability of HDL to protect LDL from oxidation [J].
Boemi, M ;
Leviev, I ;
Sirolla, C ;
Pieri, C ;
Marra, M ;
James, RW .
ATHEROSCLEROSIS, 2001, 155 (01) :229-235
[7]  
Buege J A, 1978, Methods Enzymol, V52, P302
[8]   Antioxidant effects of green tea polyphenols on free radical initiated peroxidation of rat liver microsomes [J].
Cai, YJ ;
Ma, LP ;
Hou, LF ;
Zhou, B ;
Yang, L ;
Liu, ZL .
CHEMISTRY AND PHYSICS OF LIPIDS, 2002, 120 (1-2) :109-117
[9]  
Cao HB, 1999, J LIPID RES, V40, P133
[10]  
CHAKRAVARTHY BK, 1981, LANCET, V2, P759