The influence of bexarotene, a selective agonist of the retinoid receptor X (RXR), and tazarotene, a selective agonist of the retinoid acid receptor (RAR), on bone metabolism in rats

被引:9
作者
Nowak, Beata [1 ]
Matuszewska, Agnieszka [1 ]
Filipiak, Jaroslaw [2 ]
Nikodem, Anna [2 ]
Merwid-Lad, Anna [1 ]
Piesniewska, Malgorzata [1 ]
Fereniec-Golebiewska, Lidia [1 ]
Kwiatkowska, Joanna [1 ]
Szelag, Adam [1 ]
机构
[1] Wroclaw Med Univ, Dept Pharmacol, Ul J Mikulicza Radeckiego 2, PL-50345 Wroclaw, Poland
[2] Wroclaw Univ Technol, Div Biomed Engn & Expt Mech, Wroclaw, Poland
来源
ADVANCES IN MEDICAL SCIENCES | 2016年 / 61卷 / 01期
关键词
Bone turnover; Retinoid receptor X (RXR); Retinoid acid receptor (RAR); Stress yield; VITAMIN-A; OVARIECTOMIZED RATS; IN-VITRO; PHARMACOKINETICS; DIFFERENTIATION; EXPRESSION; RESORPTION; FRACTURE; PATHWAY; HEALTH;
D O I
10.1016/j.advms.2015.09.001
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Purpose: The purpose of this study was to investigate the influence of selective agonists of the retinoid receptor X (RXR) and the retinoid acid receptor (RAR) on bone metabolism in rats. Methods: Thirty six male Wistar rats were divided into three groups: receiving bexarotene, or tazarotene, or to control group. Serum biochemical markers of bone turnover (osteocalcin - OC, tartrate resistant acid phosphatase 5 - TRACP5b and osteoprotegerin - OPG) and mechanical properties of bones were analyzed. Results: There was a significant decrease in the femur index value in groups receiving tazarotene and bexarotene on Day 14 (8% and 20% respectively, p = 0.0039). On Day 28, 14 days after discontinuation of tazarotene and bexarotene, the difference in femur indexes was still significant (4% for T1-6 and B1-6, p = 0.0270). In the bexarotene group an increase in mean plasma osteocalcin level and mean plasma TRACP5b level was detected. In the tazarotene group the mean osteocalcin level remained unchanged and the mean plasma TRACP5b level decreased. An increased yield stress was detected in groups receiving retinoids comparing to controls after 14 days of tazarotene and bexarotene administration. Conclusion: Although bexarotene and tazarotene administration caused decrease in the femur index, mechanisms responsible for that effect seem to be different. Our results suggest that bexaroten increases bone turnover. On the contrary, tazaroten seems to have inhibitory effect on bone turnover. A counter influence of selective RAR and RXR agonists on the bone turnover might be the reason for inconsistency in results from published research concerning the influence of retinoids on bone metabolism. (C) 2015 Medical University of Bialystok. Published by Elsevier Sp. z o.o. All rights reserved.
引用
收藏
页码:85 / 89
页数:5
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