Icariin upregulates phosphorylated cyclic adenosine monophosphate response element binding protein levels in the hippocampus of the senescence-accelerated mouse

被引：7

作者：

Zhang, Zhanwei ^{[2
]}

Zhang, Ting ^{[1
]}

Dong, Keli ^{[1
]}

机构：

[1] Cent S Univ, Xiangya Hosp 3, Dept Tradit Chinese Med, Changsha 410013, Hunan, Peoples R China

[2] Hunan Univ Chinese Med, Affiliated Hosp 1, Dept Neurosurg, Changsha 410007, Hunan, Peoples R China

来源：

NEURAL REGENERATION RESEARCH | 2012年 / 7卷 / 12期

关键词：

icariin; Alzheimer's disease; hippocampus; phosphorylated cyclic adenosine monophosphate response element binding protein; neural regeneration; TRANSCRIPTION FACTORS; MEMORY IMPAIRMENT; GENE-TRANSFER; MODEL; INHIBITION;

D O I：

10.3969/j.issn.1673-5374.2012.12.001

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

At 8 weeks after intragastric administration of icariin to senescence-accelerated mice (P8 strain), Morris water maze results showed that escape latency was shortened, and the number of platform crossings was increased. Immunohistochemical staining and western blot assay detected significantly increased levels of cyclic adenosine monophosphate response element binding protein. These results suggest that icariin upregulates phosphorylated cyclic adenosine monophosphate response element binding protein levels and improves learning and memory functions in hippocampus of the senescence-accelerated mouse.

引用

页码：885 / 890

页数：6

共 20 条

[1] Expression of the cAMP response element binding protein (CREB) in hippocampus produces an antidepressant effect [J].

Chen, ACH ;

Shirayama, Y ;

Shin, KH ;

Neve, RL ;

Duman, RS .

BIOLOGICAL PSYCHIATRY, 2001, 49 (09) :753-762

[2] Persistent improvement in synaptic and cognitive functions in an Alzheimer mouse model after rolipram treatment [J].

Gong, B ;

Vitolo, OV ;

Trinchese, F ;

Liu, SM ;

Shelanski, M ;

Arancio, O .

JOURNAL OF CLINICAL INVESTIGATION, 2004, 114 (11) :1624-1634

[3] Presenilin dysfunction leads to memory and plasticity defects [J].

Hayward, P .

LANCET NEUROLOGY, 2004, 3 (06) :327-327

[4] Neuroprotective effects of icariin on memory impairment and neurochemical deficits in senescence-accelerated mouse prone 8 (SAMP8) mice [J].

He, Xiao-Li ;

Zhou, Wei-Qin ;

Bi, Ming-Gang ;

Du, Guan-Hua .

BRAIN RESEARCH, 2010, 1334 :73-83

[5] Nuclear transcription factors in the hippocampus [J].

Hinoi, E ;

Balcar, VJ ;

Kuramoto, N ;

Nakamichi, N ;

Yoneda, Y .

PROGRESS IN NEUROBIOLOGY, 2002, 68 (02) :145-165

[6] Persistent phosphorylation of cyclic AMP responsive element-binding protein and activating transcription factor-2 transcription factors following transient cerebral ischemia in rat brain [J].

Hu, BR ;

Fux, CM ;

Martone, ME ;

Zivin, JA ;

Ellisman, MH .

NEUROSCIENCE, 1999, 89 (02) :437-452

[7] Neuroscience - The molecular biology of memory storage: A dialogue between genes and synapses [J].

Kandel, ER .

SCIENCE, 2001, 294 (5544) :1030-1038

[8] Somatic gene transfer of cAMP response element-binding protein attenuates memory impairment in aging rats [J].

Mouravlev, A ;

Dunning, J ;

Young, D ;

During, MJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (12) :4705-4710

[9] Age-related defects in lifespan and learning ability in SAMP8 mice [J].

Nomura, Y ;

Okuma, Y .

NEUROBIOLOGY OF AGING, 1999, 20 (02) :111-115

[10] Intraneuronal amyloid β accumulation and oxidative damage to nucleic acids in Alzheimer disease [J].

Nunomura, Akihiko ;

Tamaoki, Toshio ;

Tanaka, Koich ;

Motohashi, Nobutaka ;

Nakamura, Masao ;

Hayashi, Takaaki ;

Yamaguchi, Haruyasu ;

Shimohama, Shun ;

Lee, Hyoung-gon ;

Zhu, Xiongwei ;

Smith, Mark A. ;

Perry, George .

NEUROBIOLOGY OF DISEASE, 2010, 37 (03) :731-737

← 1 2 →