Antibiotics in the Management of PROM and Preterm Labor

被引：36
作者：
Mercer, Brian [1 ,2 ]
机构：
[1] MetroHlth Med Ctr, Dept Obstet & Maternal Fetal Med, Cleveland, OH 44109 USA
[2] Case Western Reserve Univ, Dept Reprod Biol, Cleveland, OH 44106 USA
来源：
OBSTETRICS AND GYNECOLOGY CLINICS OF NORTH AMERICA | 2012年 / 39卷 / 01期
关键词：
Antibiotics; Preterm labor; Preterm PROM; Premature rupture of the membranes; BROAD-SPECTRUM ANTIBIOTICS; AMNIOTIC-FLUID INFECTION; PLACEBO-CONTROLLED TRIAL; 7-YEAR FOLLOW-UP; PREMATURE RUPTURE; CERVICAL LENGTH; DOUBLE-BLIND; PREGNANT-WOMEN; HISTOLOGIC CHORIOAMNIONITIS; SONOGRAPHIC MEASUREMENT;
D O I：
10.1016/j.ogc.2011.12.007
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
A significant fraction of preterm birth results from subclinical intrauterine infection. Antimicrobial treatment during conservative management of preterm labor and premature rupture of the membranes (PROM) remote from term could treat subclinical decidual colonization. There are data supporting adjunctive antibiotic treatment during conservative management of PROM remote from term, including broad-spectrum agents. There is no consistent evidence that antibiotic treatment in the setting of preterm labor with intact membranes prolongs pregnancy or improves newborn outcomes; there is some evidence of risk. Antibiotic treatment for pregnancy prolongation should not be offered in the setting of preterm labor with intact membranes.
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页码：65 / +
页数：13
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