Electrospun Non-Woven Nanofibrous Hybrid Mats Based on Chitosan and PLA for Wound-Dressing Applications

被引：157

作者：

Ignatova, Milena ^{[1
]}

Manolova, Nevena ^{[1
]}

Markova, Nadya ^{[2
]}

Rashkov, Iliya ^{[1
]}

机构：

[1] Bulgarian Acad Sci, Inst Polymer, Lab Bioact Polymers, BU-1113 Sofia, Bulgaria

[2] Bulgarian Acad Sci, Inst Microbiol, BU-1113 Sofia, Bulgaria

来源：

MACROMOLECULAR BIOSCIENCE | 2009年 / 9卷 / 01期

关键词：

antibacterial activity; chitosan; electrospinning; nanotechnology; poly[(L-lactide)-co-(D; L-lactide); wound healing; ANTIBACTERIAL ACTIVITY; ANTIMICROBIAL ACTIVITY; QUATERNIZED CHITOSAN; DRUG-DELIVERY; CROSS-LINKING; ACETIC-ACID; FIBERS; POLYMER; DEGRADATION; MORPHOLOGY;

D O I：

10.1002/mabi.200800189

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Continuous defect-free nanofibers containing chitosan (Ch) or quaternized chitosan (QCh) were successfully prepared by one-step electrospinning of Ch or QCh solutions mixed with poly[(L-lactide)-co-(D,L-lactide)] in common solvent. XPS revealed the surface chemical composition of the bicomponent electrospun mats. Crosslinked Ch- and QCh-containing nanofibers exhibited higher kill rates against bacteria S. aureus and E. coli than the corresponding solvent-cast films. SEM observations showed that hybrid mats were very effective in suppressing the adhesion of pathogenic bacteria S. aureus. The hybrid nanofibers are promising for wound-healing applications. containing chitosan step electrospinning

引用

页码：102 / 111

页数：10

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