The influence of early neutrophil-Leishmania interactions on the host immune response to infection

被引：106

作者：

Ribeiro-Gomes, Flavia L. ^{[1
]}

Sacks, David ^{[1
]}

机构：

[1] NIAID, Parasit Dis Lab, NIH, Bethesda, MD 20892 USA

来源：

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY | 2012年 / 2卷

基金：

美国国家卫生研究院;

关键词：

neutrophils; Leishmania; inflammation; immune response; sand fly; apoptosis; dendritic cells; macrophages; CUTANEOUS LEISHMANIASIS; DONOVANI PROMASTIGOTES; MONOCLONAL-ANTIBODY; MAJOR INFECTION; PARASITE BURDEN; LYMPH-NODES; CELLS; GRANULOCYTES; MICE; RESISTANT;

D O I：

10.3389/fcimb.2012.00059

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Neutrophils are the first cells recruited to the dermal site of Leishrnania infection following injection by needle or sand fly bite. The role of neutrophils in either promoting or suppressing host immunity remains controversial. We discuss the events driving neutrophil recruitment, their interaction with the parasite and apoptotic fate, and the nature of their encounters with other innate cells. We suggest that the influence of the neutrophil response on infection outcome critically depends on the timing of their recruitment and the tissue environment in which it occurs.

引用

页数：8

共 59 条

[1] Interactions with apoptotic but not with necrotic neutrophils increase parasite burden in human macrophages infected with Leishmania amazonensis [J].

Afonso, Lilian ;

Borges, Valeria M. ;

Cruz, Heloisa ;

Ribeiro-Gomes, Flavia L. ;

DosReis, George A. ;

Dutra, Alberto Noronha ;

Clarencio, Jorge ;

de Oliveira, Camila I. ;

Barral, Aldina ;

Barral-Netto, Manoel ;

Brodskyn, Claudia I. .

JOURNAL OF LEUKOCYTE BIOLOGY, 2008, 84 (02) :389-396

[2] Inhibition of the spontaneous apoptosis of neutrophil granulocytes by the intracellular parasite Leishmania major [J].

Aga, E ;

Katschinski, DM ;

van Zandbergen, G ;

Laufs, H ;

Hansen, B ;

Müller, K ;

Solbach, W ;

Laskay, T .

JOURNAL OF IMMUNOLOGY, 2002, 169 (02) :898-905

[3] EFFECT OF LEISHMANIA-MAJOR ON HUMAN POLYMORPHONUCLEAR LEUKOCYTE FUNCTION-INVITRO [J].

ALTUWAIJRI, AS ;

ALMOFLEH, IA ;

MAHMOUD, AA .

JOURNAL OF MEDICAL MICROBIOLOGY, 1990, 32 (03) :189-193

[4]

ANDRADE ZA, 1984, AM J PATHOL, V114, P137

[5] DIFFERENCES IN THE ONSET OF THE INFLAMMATORY RESPONSE TO CUTANEOUS LEISHMANIASIS IN RESISTANT AND SUSCEPTIBLE MICE [J].

BEIL, WJ ;

MEINARDUSHAGER, G ;

NEUGEBAUER, DC ;

SORG, C .

JOURNAL OF LEUKOCYTE BIOLOGY, 1992, 52 (02) :135-142

[6] LEISHMANICIDAL MECHANISMS OF HUMAN POLYMORPHONUCLEAR PHAGOCYTES [J].

CHANG, KP .

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 1981, 30 (02) :322-333

[7] Leishmania major induces distinct neutrophil phenotypes in mice that are resistant or susceptible to infection [J].

Charmoy, Melanie ;

Megnekou, Rosette ;

Allenbach, Cindy ;

Zweifel, Christine ;

Perez, Cynthia ;

Monnat, Katia ;

Breton, Melanie ;

Ronet, Catherine ;

Launois, Pascal ;

Tacchini-Cottier, Fabienne .

JOURNAL OF LEUKOCYTE BIOLOGY, 2007, 82 (02) :288-299

[8] The Prominent Role of Neutrophils during the Initial Phase of Infection by Leishmania Parasites [J].

Charmoy, Melanie ;

Auderset, Floriane ;

Allenbach, Cindy ;

Tacchini-Cottier, Fabienne .

JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY, 2010,

[9] Neutrophil-Derived CCL3 Is Essential for the Rapid Recruitment of Dendritic Cells to the Site of Leishmania major Inoculation in Resistant Mice [J].

Charmoy, Melanie ;

Brunner-Agten, Saskia ;

Aebischer, David ;

Auderset, Floriane ;

Launois, Pascal ;

Milon, Genevieve ;

Proudfoot, Amanda E. I. ;

Tacchini-Cottier, Fabienne .

PLOS PATHOGENS, 2010, 6 (02)

[10] The involvement of neutrophils in the resistance to Leishmania major infection in susceptible but not in resistant mice [J].

Chen, L ;

Zhang, ZH ;

Watanabe, T ;

Yamashita, T ;

Kobayakawa, T ;

Kaneko, A ;

Fujiwara, H ;

Sendo, F .

PARASITOLOGY INTERNATIONAL, 2005, 54 (02) :109-118

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