Stem Cells and Calcium Signaling

被引：113

作者：

Tonelli, Fernanda M. P. ^{[1
]}

Santos, Anderson K. ^{[1
]}

Gomes, Dawidson A. ^{[2
]}

da Silva, Saulo L. ^{[3
]}

Gomes, Katia N. ^{[1
]}

Ladeira, Luiz O. ^{[1
]}

Resende, Rodrigo R. ^{[1
]}

机构：

[1] Univ Fed Minas Gerais, Nanomat Lab, Dept Phys, Inst Exact Sci, BR-31270901 Belo Horizonte, MG, Brazil

[2] Univ Fed Minas Gerais, Dept Biochem & Immunol, Inst Biol Sci, BR-31270901 Belo Horizonte, MG, Brazil

[3] Univ Fed Sao Joao Del Rei Campus Alto Paraopeba, BR-36420000 Ouro Branco, MG, Brazil

来源：

CALCIUM SIGNALING | 2012年 / 740卷

关键词：

Calcium transients; Embryonic stem cells; GPCR and RTK receptors; Calcium signaling; Stem cells differentiation; NEURONAL DIFFERENTIATION; EMBRYONAL CARCINOMA; GENE-EXPRESSION; INOSITOL TRISPHOSPHATE; ADENYLYL CYCLASES; CA2+ OSCILLATIONS; NEURAL INDUCTION; SELF-RENEWAL; ACTIVATION; PROLIFERATION;

D O I：

10.1007/978-94-007-2888-2_40

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The increasing interest in stem cell research is linked to the promise of developing treatments for many lifethreatening, debilitating diseases, and for cell replacement therapies. However, performing these therapeutic innovations with safety will only be possible when an accurate knowledge about the molecular signals that promote the desired cell fate is reached. Among these signals are transient changes in intracellular Ca2+ concentration [Ca2+](i). Acting as an intracellular messenger, Ca2+ has a key role in cell signaling pathways in various differentiation stages of stem cells. The aim of this chapter is to present a broad overview of various moments in which Ca2+-mediated signaling is essential for the maintenance of stem cells and for promoting their development and differentiation, also focusing on their therapeutic potential.

引用

页码：891 / 916

页数：26

共 124 条

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