Growth inhibition and mutagenesis induced in Escherichia coli by dihydropyrazines with DNA strand-cleaving activity

被引：22

作者：

Takechia, S ^{[1
]}

Yamaguchi, T

Nomura, H

Minematsu, T

Nakayama, T

机构：

[1] Miyazaki Med Coll, Dept Biochem, Kiyotake, Miyazaki 8891692, Japan

[2] Miyazaki Med Coll, Dept Hyg, Kiyotake, Miyazaki 8891692, Japan

[3] Miyazaki Med Coll, Dept Lab Med, Kiyotake, Miyazaki 8891692, Japan

[4] Aisenhai Nichinan Hosp, Inst Dis Control, Miyazaki 8870034, Japan

来源：

MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS | 2004年 / 560卷 / 01期

关键词：

dihydropyrazine; Escherichia coli; DNA damage; growth inhibition; mutagenicity;

D O I：

10.1016/j.mrgentox.2004.02.007

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Dihydropyrazine (DHP) causes DNA strand breaks in vitro. We evaluated the cytotoxic and genotoxic potential of DHP in Escherichia coli. DHP exposure dose-dependently caused inhibition of cell growth in the wild-type strain, death in recA and uvrB, and an increase in mutation frequency in uvrB. These findings indicate that DHP causes DNA strand breaks in vivo. (C) 2004 Elsevier B.V. All rights reserved.

引用

页码：49 / 55

页数：7

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