Predictors of the risk of fibrosis at 10 years after breast conserving therapy for early breast cancer - A study based on the EORTC trial 22881-10882 'boost versus no boost'

被引：167

作者：

Collette, Sandra ^{[1
]}

Collette, Laurence ^{[1
]}

Budiharto, Tom ^{[1
]}

Horiot, Jean-Claude ^{[2
]}

Poortmans, Philip M. ^{[3
]}

Struikmans, Henk ^{[4
]}

Van den Bogaer, Walter ^{[5
]}

Fourquet, Alain ^{[6
]}

Jagerg, Jos J. ^{[7
]}

Hoogenraad, Willem ^{[8
]}

Mueller, Rolf-Peter ^{[9
]}

Kurtz, John ^{[10
]}

Morgan, David A. L. ^{[11
]}

Dubois, Jean-Bernard ^{[12
]}

Salamon, Emile ^{[13
]}

Mirimanoff, Rene ^{[14
]}

Bolla, Michel ^{[15
]}

Van der Hulst, Marleen ^{[3
]}

Warlam-Rodenhuis, Carla C. ^{[16
]}

Bartelink, Harry ^{[17
]}

机构：

[1] EORTC Headquarters, Dept Stat, Brussels, Belgium

[2] Ctr Georges Francois Leclerc, Dept Radiat Oncol, Dijon, France

[3] Dr Bernard Verbeeten Inst, Dept Radiat Oncol, Tilburg, Netherlands

[4] Leiden Univ, Med Ctr, Dept Radiat Oncol, Leiden, Netherlands

[5] Univ Hosp Gasthuisberg, Dept Radiat Oncol, B-3000 Louvain, Belgium

[6] Inst Curie, Dept Radiat Oncol, Paris, France

[7] Radiotherapeut Inst Limburg, Dept Radiat Oncol, Heerlen, Netherlands

[8] Radboud Univ Nijmegen, Med Ctr, Dept Radiat Oncol, NL-6525 ED Nijmegen, Netherlands

[9] Univ Kliniken Koln, Dept Radiat Oncol, Cologne, Germany

[10] Hosp Cantonal Univ Geneva, Dept Radiat Oncol, Geneva, Switzerland

[11] City Hosp Nottingham, Dept Radiat Oncol, Nottingham, England

[12] CRLC Val Aurelle, Dept Radiat Oncol, Montpellier, France

[13] Clin St Elizabeth, Dept Radiat Oncol, Namur, Belgium

[14] CHU Vaudois, Dept Radiat Oncol, CH-1011 Lausanne, Switzerland

[15] CHU Grenoble, Dept Radiat Oncol, F-38043 Grenoble, France

[16] Univ Med Ctr, Dept Radiat Oncol, Utrecht, Netherlands

[17] Netherlands Canc Inst, Dept Radiat Oncol, Amsterdam, Netherlands

来源：

EUROPEAN JOURNAL OF CANCER | 2008年 / 44卷 / 17期

关键词：

Fibrosis; Breast conserving treatment; Boost irradiation; Nomograms; Early breast cancer;

D O I：

10.1016/j.ejca.2008.07.032

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The EORTC 22881-10882 trial in 5178 conservatively treated early breast cancer patients showed that a 16 Gy boost dose significantly improved local control, but increased the risk of breast fibrosis. To investigate predictors for the long-term risk of fibrosis, Cox regression models of the time to moderate or severe fibrosis were developed on a random set of 1797 patients with and 1827 patients without a boost, and validated in the remaining set. The median follow-up was 10.7 years. The risk of fibrosis significantly increased (P < 0.01) with increasing maximum whole breast irradiation (WBI) dose and with concomitant chernotherapy, but was independent of age. In the boost arm, the risk further increased (P < 0.01) if patients had post-operative breast oedema or haematoma, but it decreased (P < 0.01) if WBI was given with >6 MV photons. The c-index was around 0.62. Nomograms with these factors are proposed to forecast the long-term risk of moderate or severe fibrosis. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：2587 / 2599

页数：13

共 29 条

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