Antimicrobial surveillance of Haemophilus influenzae in the United States during 2000-2001 leads to detection of clonal dissemination of a β-lactamase-negative and ampicillin-resistant strain

被引：41

作者：

Karlowsky, JA ^{[1
]}

Critchley, IA ^{[1
]}

Blosser-Middleton, RS ^{[1
]}

Karginova, EA ^{[1
]}

Jones, ME ^{[1
]}

Thornsberry, C ^{[1
]}

Sahm, DF ^{[1
]}

机构：

[1] Focus Technol Inc, Herndon, VA 20171 USA

来源：

JOURNAL OF CLINICAL MICROBIOLOGY | 2002年 / 40卷 / 03期

关键词：

D O I：

10.1128/JCM.40.3.1063-1066.2002

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

A 2000-2001 U.S. Haemophilus influenzae surveillance study (n = 1,434) detected nine (0.6%) beta-lactamase-negative and ampicillin-resistant (BLNAR) isolates collected from two different hospitals. The MICs of ampicillin for all nine isolates were 4 mug/ml, with results being reproducible; and all nine isolates were susceptible to amoxicillin-clavulanate, cefuroxime, cefprozil, macrolides, and fluoroquinolones. Pulsed-field gel electrophoresis of genomic DNA following Small digestion demonstrated identical patterns for each of the nine isolates, suggesting intra- and interhospital dissemination of a BLNAR clone.

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页码：1063 / 1066

页数：4

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