Antioxidant and anti-inflammatory activities of the plant Andrographis panicullata nees

被引：114

作者：

Sheeja, K ^{[1
]}

Shihab, PK ^{[1
]}

Kuttan, G ^{[1
]}

机构：

[1] Amala Canc Res Ctr, Kerala, India

来源：

IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY | 2006年 / 28卷 / 01期

关键词：

antioxidant; anti-inflammation; Andrographis paniculata;

D O I：

10.1080/08923970600626007

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In this study, we explored the antioxidant and anti-inflammatory properties of the medicinal herb Andrographis paniculata using in vitro as well as in vivo systems. Methanolic extract of Andrographis paniculata was found to inhibit formation of oxygen derived free radicals such as superoxide (32%) hydroxyl radicals (80%) lipid peroxidation (80%) and nitric oxide (42.8%) in in vitro system. In vivo studies using BALB/c mice models also showed significant inhibition in PMA induced superoxide (32.4%) and nitric oxide (65.3%) formation. Interestingly we also found that, administration of Andrographis paniculata extract produced complete inhibition of carageenan induced inflammation compared with control models.

引用

页码：129 / 140

页数：12

共 41 条

[1]

[Anonymous], 1995, J AM DIET ASSOC, V95, P493

[2]

ATHAR M, 2000, INDIAN J EXP BIOL, V40, P656

[3] Nitric oxide levels and lipid peroxidation in plasma of patients with gastric cancer [J].