Increased circulating platelet microparticles as a potential biomarker in asthma

被引：49

作者：

Duarte, D. ^{[1
]}

Taveira-Gomes, T. ^{[1
]}

Sokhatska, O. ^{[2
]}

Palmares, C. ^{[2
]}

Costa, R. ^{[1
]}

Negrao, R. ^{[1
]}

Guimaraes, J. T. ^{[1
,3
]}

Delgado, L. ^{[2
,3
,4
]}

Soares, R. ^{[1
]}

Moreira, A. ^{[2
,4
]}

机构：

[1] Univ Porto, Dept Biochem FCT U38, Fac Med, P-4200450 Oporto, Portugal

[2] Univ Porto, Dept Immunol, Fac Med, P-4200450 Oporto, Portugal

[3] Cent Hosp Sao Joao, Dept Clin Pathol, Oporto, Portugal

[4] Cent Hosp Sao Joao, Dept Immunoallergol, Oporto, Portugal

来源：

ALLERGY | 2013年 / 68卷 / 08期

关键词：

apoptosis; asthma; endothelial and platelet microparticles; sICAM-1; VEGF; ENDOTHELIAL MICROPARTICLES; INFLAMMATION;

D O I：

10.1111/all.12190

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Background: Endothelial (EMPs) and platelet microparticles (PMPs) have been studied as biomarkers in several inflammatory diseases and as central players in intercellular communication. Methods: In this cross-sectional study, we aimed to assess microparticle levels in asthma. Circulating microparticles and inflammatory and angiogenic markers were assessed by clinical and laboratorial evaluation, flow cytometry, and immunoassays, in a group of 20 asthmatic and 15 nonasthmatic subjects. Results: Circulating levels of PMPs (either CD31+/42b+ or CD31+/42b+/AnV+) were significantly increased in asthmatics (P=0.021) even after adjustment for confounders. Apoptotic EMPs (CD31+/42b--/AnV+) were significantly increased before (P=0.005) but not after adjustments (P=0.117). Conclusions: We propose that PMPs may be putative asthma biomarkers, playing a role in asthma pathophysiology.

引用

页码：1073 / 1075

页数：3

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