Equine Lyme Disease

被引:17
作者
Divers, Thomas J. [1 ]
机构
[1] Cornell Univ, Coll Vet Med, Ithaca, NY 14853 USA
关键词
Lyme; Borrelia; Tick-borne; BORRELIA-BURGDORFERI INFECTION; MINIMUM INHIBITORY CONCENTRATIONS; CYSTIC FORMS; IN-VITRO; HORSES; ANTIBODY; DOXYCYCLINE; PONIES; TICKS; PHARMACOKINETICS;
D O I
10.1016/j.jevs.2013.03.187
中图分类号
S85 [动物医学(兽医学)];
学科分类号
0906 ;
摘要
Borrelia burgdorferi infection in horses is common in some areas of North America, but the incidence of clinical disease has not been determined, which makes Lyme disease controversial in the horse. Progress is being made case by case in defining the several clinical presentations of Lyme disease in adult horses. Current serologic tests are very sensitive and specific for detecting either infection (previous or concurrent) or exposure but may not distinguish between them. Treatment protocols are available for Lyme disease in horses; however, the ability of those protocols to eliminate the organism remains questionable. Currently, minocycline is being attempted in some presumed Lyme cases as an improved alternative to doxycycline and oxytetracycline. Vaccination, like many aspects of Lyme disease, remains controversial, although the canine-approved vaccines have the potential to prevent infection based upon vaccine studies in ponies and other animals. (C) 2013 Elsevier Inc. All rights reserved.
引用
收藏
页码:488 / 492
页数:5
相关论文
共 46 条
[1]   Borrelia burgdorferi-induced inflammation facilitates spirochete adaptation and variable major protein-like sequence locus recombination [J].
Anguita, J ;
Thomas, V ;
Samanta, S ;
Persinski, R ;
Hernanz, C ;
Barthold, SW ;
Fikrig, E .
JOURNAL OF IMMUNOLOGY, 2001, 167 (06) :3383-3390
[2]   Antiscience and ethical concerns associated with advocacy of Lyme disease [J].
Auwaerter, Paul G. ;
Bakken, Johan S. ;
Dattwyler, Raymond J. ;
Dumler, J. Stephen ;
Halperin, John J. ;
McSweegan, Edward ;
Nadelman, Robert B. ;
O'Connell, Susan ;
Shapiro, Eugene D. ;
Sood, Sunil K. ;
Steere, Allen C. ;
Weinstein, Arthur ;
Wormser, Gary P. .
LANCET INFECTIOUS DISEASES, 2011, 11 (09) :713-719
[3]   An in vitro study of the susceptibility of mobile and cystic forms of Borrelia burgdorferi to metronidazole [J].
Brorson, O ;
Brorson, SH .
APMIS, 1999, 107 (06) :566-576
[4]   LAMENESS ASSOCIATED WITH BORRELIA-BURGDORFERI INFECTION IN THE HORSE [J].
BROWNING, A ;
CARTER, SD ;
BARNES, A ;
MAY, C ;
BENNETT, D .
VETERINARY RECORD, 1993, 132 (24) :610-611
[5]   Study of intragastric administration of doxycycline: pharmacokinetics including body fluid, endometrial and minimum inhibitory concentrations [J].
Bryant, JE ;
Brown, MP ;
Gronwall, RR ;
Merritt, KA .
EQUINE VETERINARY JOURNAL, 2000, 32 (03) :233-238
[6]  
BURGDORFER W, 1984, YALE J BIOL MED, V57, P515
[7]  
BURGESS EC, 1987, J AM VET MED ASSOC, V191, P1457
[8]   BORRELIA-BURGDORFERI INFECTION IN WISCONSIN HORSES AND COWS [J].
BURGESS, EC .
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1988, 539 :235-243
[9]   Antibiotic treatment of experimentally Borrelia burgdorferi-infected ponies [J].
Chang, YF ;
Ku, YW ;
Chang, CF ;
Chang, CD ;
McDonough, SR ;
Divers, T ;
Pough, M ;
Torres, A .
VETERINARY MICROBIOLOGY, 2005, 107 (3-4) :285-294
[10]   Experimental infection of ponies with Borrelia burgdorferi by exposure to ixodid ticks [J].
Chang, YF ;
Novosol, V ;
McDonough, SP ;
Chang, CF ;
Jacobson, RH ;
Divers, T ;
Quimby, FW ;
Shin, S ;
Lein, DH .
VETERINARY PATHOLOGY, 2000, 37 (01) :68-76