Synthesis and evaluation of a 99mTc-labeled deoxyglucose derivative as a potential agent to target tumor

被引：5

作者：

Wang, Yue ^{[1
]}

Song, Xiaoqing ^{[1
]}

Zhang, Junbo ^{[1
]}

机构：

[1] Beijing Normal Univ, Coll Chem, Key Lab Radiopharmaceut, Minist Educ, Beijing 100875, Peoples R China

来源：

JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY | 2015年 / 306卷 / 02期

基金：

北京市自然科学基金; 中国国家自然科学基金;

关键词：

D-glucose derivative; (99)mTc; SPECT; Tumor diagnosis; IMAGING AGENT; BIOLOGICAL EVALUATION; D-GLUCOSE; DITHIOCARBAMATE; BIODISTRIBUTION; COMPLEX; TC-99M-OXO; SPECT;

D O I：

10.1007/s10967-015-4109-2

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

In this study, ethylene diamine tetraacetic acid-deoxyglucose (EDTADG) ligand was successfully synthesized and then radiolabeled with Tc-99m directly to produce Tc-99m-EDTADG with high radiochemical purity. Tc-99m-EDTADG showed good in vitro stability. The partition coefficient and electrophoresis results showed it was hydrophilic and negatively charged. The biodistribution study in mice bearing S180 tumor showed that Tc-99m-EDTADG had high accumulation in tumor tissue with high tumor-to-muscle and tumor-to-blood ratios. Single photon emission computed tomography imaging clearly visualized the tumor, suggesting it could be considered as a potential agent for tumor imaging.

引用

页码：477 / 482

页数：6

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