HLA-G: from feto-maternal tolerance to organ acceptance

被引：0

作者：

Carosella, Edgardo D. ^{[1
]}

机构：

[1] Hop St Louis, Inst Univ Hematol, CEA SRHI, 1 Ave Claude Velle Faux, F-75010 Paris, France

来源：

BULLETIN DE L ACADEMIE NATIONALE DE MEDECINE | 2014年 / 198卷 / 4-5期

关键词：

HLA ANTIGENS; IMMUNE TOLERANCE; PREGNANCY; TRANSPLANTATION;

D O I：

10.1016/S0001-4079(19)31288-9

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

HLA-G is a nonclassical class I molecule that differs from classical antigens by its restricted expression, very low polymorphism, expression of 7 different protein isoforms, and immune tolerance-inducing activity. HLA-G plays a key role in feto-maternal tolerance. Its interaction with three specific receptors expressed on immune cells (T, B, natural killer and antigen-presenting cells) allows it to act at all levels of the immune response. HLA-G can also be expressed by tumor cells and their microenvironment, endowing them with significant local tolerance. The same is true in some inflammatory and viral diseases.

引用

页码：801 / 812

页数：12

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