A self-delivery membrane system for enhanced anti-tumor therapy

被引:45
作者
Qiu, Wen-Xiu
Zhang, Ming-Kang
Liu, Li-Han
Gao, Fan
Zhang, Lu
Li, Shi-Ying
Xie, Bo-Ru
Zhang, Chi
Feng, Jun
Zhang, Xian-Zheng [1 ]
机构
[1] Wuhan Univ, Minist Educ, Key Lab Biomed Polymers, Wuhan 430072, Hubei, Peoples R China
基金
中国国家自然科学基金;
关键词
Chimeric peptide; Self-delivery; Membrane target; Anti-tumor therapy; Immune response; DRUG-DELIVERY; CELL-MEMBRANE; PHOTODYNAMIC THERAPY; COATED NANOPARTICLES; CIRCULATION TIME; BREAST-CANCER; MICELLES; PH; INTERNALIZATION; TOXICITY;
D O I
10.1016/j.biomaterials.2018.01.037
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
Nowadays, cell membrane targeting therapy has drawn much attention for its high anti-tumor effect by avoiding the cellular barriers. In this study, therapeutic agent conjugated chimeric peptide (Cp) was anchored in cracked cancer cell membranes (CCCM) to construct a self-delivery membrane system (MCp), which could relize precise cell membrane targeting therapy. It was found that compared with Cp, MCp could target to the cancer cell membrane with longer retention time, which is very crucial for in vivo applications. And the superior cell membrane targeting ability was attributed to the specific proteins (focal adhesion proteins, focal adhesion kinase, RHO family proteins, and integrin) on the CCCM surface. Importantly, the M-Cp could promote tumor-specific immune response, which further enhanced antitumor effect when combined with therapeutic agents in M-Cp. What's more, this self-delivery membrane system could be used as a template for cell membrane targeting therapy by changing the therapeutic agents as well as the CCCM, and this strategy would open a new window for various cell membrane targeting therapy. (C) 2018 Elsevier Ltd. All rights reserved.
引用
收藏
页码:81 / 94
页数:14
相关论文
共 50 条
[41]   PEGylated poly(diselenide-phosphate) nanogel as efficient self-delivery nanomedicine for cancer therapy [J].
Li, Chunting ;
Huang, Wei ;
Zhou, Linzhu ;
Huang, Ping ;
Pang, Yan ;
Zhu, Xinyuan ;
Yan, Deyue .
POLYMER CHEMISTRY, 2015, 6 (36) :6498-6508
[42]   Electrostatic Attractive Self-Delivery of siRNA and Light-Induced Self-Escape for Synergistic Gene Therapy [J].
Yang, Yuxin ;
Ning, Haijun ;
Xia, Tianping ;
Du, Jianjun ;
Sun, Wen ;
Fan, Jiangli ;
Peng, Xiaojun .
ADVANCED MATERIALS, 2023, 35 (30)
[43]   Tumor Targeting Chemo- and Photodynamic Therapy Packaged in Albumin for Enhanced Anti-Tumor Efficacy [J].
Zheng, Ke ;
Liu, Hongyan ;
Liu, Xinxin ;
Wang, Ying ;
Li, Linlin ;
Li, Shijie ;
Xue, Jinping ;
Huang, Mingdong .
INTERNATIONAL JOURNAL OF NANOMEDICINE, 2020, 15 :151-167
[44]   Fabrication of pH/H2O2-responsive polyhedral oligomeric silsesquioxane self-assembled fluorescent vesicles for enhanced in vivo anti-tumor efficacy [J].
Ren, Shuxian ;
Zhang, Guiyang ;
Shi, Wanling ;
Li, Weizhi ;
Jia, Xudong .
NANOMEDICINE, 2022, 17 (10) :671-682
[45]   Targeting cuproptosis for cancer therapy: Focus on the anti-tumor immune system☆ [J].
Zhang, Xuan ;
Han, Xiaohong .
CANCER PATHOGENESIS AND THERAPY, 2025, 3 (03) :226-243
[46]   Self-delivery nanodrug to manipulate tumor microenvironment for boosting photodynamic cancer immunotherapy [J].
Feng, Xianquan ;
Zeng, Lingjun ;
Wu, Lina ;
Chen, Zhenzhen ;
Lin, Wanjing ;
Song, Hongtao ;
Lan, Fenghua .
BIOMEDICINE & PHARMACOTHERAPY, 2024, 178
[47]   Self-Delivery Nanoparticles of Amphiphilic Acyclic Enediynes for Efficient Tumor Cell Suppression [J].
Li, Jing ;
Wu, Yuequn ;
Sun, Lili ;
Huang, Shuai ;
Li, Baojun ;
Ding, Yun ;
Hu, Aiguo .
CHINESE JOURNAL OF CHEMISTRY, 2019, 37 (05) :479-485
[48]   A self-delivery chimeric peptide for high efficient cell membrane-targeting low-temperature photothermal/photodynamic combinational therapy and metastasis suppression of tumor [J].
Chen, Pei-Ling ;
Huang, Pei-Ying ;
Chen, Jiao-Yu ;
Shi, Qun-Ying ;
Zhu, Yin-Yin ;
Chen, Yi ;
Liu, Li-Han ;
Zhang, Xian-Zheng .
BIOMATERIALS, 2022, 286
[49]   An effective tumor-targeting strategy utilizing hypoxia-sensitive siRNA delivery system for improved anti-tumor outcome [J].
Kang, Lin ;
Fan, Bo ;
Sun, Ping ;
Huang, Wei ;
Jin, Mingji ;
Wang, Qiming ;
Gao, Zhonggao .
ACTA BIOMATERIALIA, 2016, 44 :341-354
[50]   Endogenous Enzyme-responsive Nanoplatforms for Anti-tumor Therapy [J].
Lou, Xue-Fang ;
Du, Yong-Zhong ;
Xu, Xiao-Ling .
CURRENT DRUG TARGETS, 2021, 22 (08) :845-855