Effect of exercise training on neuromuscular function of elbow flexors and knee extensors of type 2 diabetic patients

被引:22
作者
Bazzucchi, I. [1 ]
De Vito, G. [2 ]
Felici, F. [1 ]
Dewhurst, S. [3 ]
Sgadari, A. [4 ]
Sacchetti, M. [1 ]
机构
[1] Univ Rome Foro Italico, Dept Movement Human & Hlth Sci, I-00135 Rome, Italy
[2] Univ Coll Dublin, Inst Sport & Hlth, Belfield D4, Ireland
[3] Univ Cumbria, Dept Med & Sport Sci, Lancaster LA1 3JD, England
[4] Univ Cattolica Sacro Cuore, Dept Geriatr Neurosci & Orthoped, I-00168 Rome, Italy
关键词
Type II diabetes; Electromyography; Isokinetic strength; Muscle fatigue; OXIDATIVE ENZYME-ACTIVITY; MUSCLE-FIBER COMPOSITION; SKELETAL-MUSCLE; CAPILLARY DENSITY; SARCOLEMMAL EXCITABILITY; CONDUCTION-VELOCITY; INSULIN-RESISTANCE; GLUCOSE-TRANSPORT; GLUT4; CONTENT; OLDER-ADULTS;
D O I
10.1016/j.jelekin.2015.06.008
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Purpose: The effects of exercise training on neuromuscular function of arm and leg muscles in type 2 diabetic patients (T2D) was investigated. Methods: Eight T2D sedentary male patients (61.0 +/- 2.3 years) and eight sedentary healthy age matched control subjects (H, 63.9 +/- 3.8 years) underwent a 16-week supervised combined endurance and resistance exercise program. Before and after training, maximal isometric (MVIC), isokinetic (15, 30, 60, 120, 180, 240 degrees s (1)) torque and muscle endurance of the elbow flexors (EF) and knee extensors (KE) were assessed. Simultaneously, surface electromyographic signals from biceps brachii (BB) and vastus lateralis (VL) muscles were recorded and muscle fiber conduction velocity (MFCV) estimated. Results: Following training, maximal torque of the KE increased during MVIC and isokinetic contractions at 15 and 30 degrees s (1) in the T2D (+ 19.1 +/- 2.7% on average; p < 0.05) but not in the H group (+ 7 +/- 0.9%; p > 0.05). MFCV recorded from the VL during MVIC and during isokinetic contractions at 15 and 30 degrees s (1) increased (+ 11.2 +/- 1.6% on average; p < 0.01), but in the diabetic group only. Muscular endurance was lower in T2D (20.1 +/- 0.7 s) compared to H (26.9 +/- 1.3 s), with an associated increase in the MFCV slope after training in the KE muscles only. Conclusion: The effect of a combined exercise training on muscle torque appears to be angular velocity-specific in diabetic individuals, with a more pronounced effect on KE muscles and at slow contraction velocities, along with an associated increase in the MFCV. MFCV appears to be a more sensitive marker than torque in detecting the early signs of neuromuscular function reconditioning. (C)2015 Elsevier Ltd. All rights reserved.
引用
收藏
页码:815 / 823
页数:9
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