Cu-catalyzed coupling-cyclization in PEG 400 under ultrasound: a highly selective and greener approach towards isocoumarins

被引：31
作者：
Chary, R. Gangadhara [1 ,2 ]
Reddy, G. Rajeshwar [1 ]
Ganesh, Y. S. S. [1 ]
Prasad, K. Vara [1 ]
Chandra, S. K. Phani [1 ]
Mukherjee, Soumita [3 ]
Pal, Manojit [3 ]
机构：
[1] Dr Reddys Labs Ltd, Custom Pharmaceut Serv, Hyderabad 500049, Andhra Pradesh, India
[2] JNT Univ, Hyderabad 500072, Andhra Pradesh, India
[3] Dr Reddys Inst Life Sci, Organ & Med Chem Dept, Hyderabad 500046, Andhra Pradesh, India
来源：
RSC ADVANCES | 2013年 / 3卷 / 25期
关键词：
HYDRANGEAE-DULCIS FOLIUM; O-IODOBENZOIC ACID; EFFICIENT SYNTHESIS; 3-SUBSTITUTED ISOCOUMARINS; HETEROANNULATION; LISSOCLINOLIDE; LACTONIZATION; THUNBERGINOL; DERIVATIVES; PHTHALIDES;
D O I：
10.1039/c3ra40969d
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The combination of CuI-K2CO3-PEG 400 facilitated the coupling-cyclization of o-iodobenzoic acid with terminal alkynes under ultrasound, affording a greener and practical approach towards 3-substituted isocoumarins with remarkable regioselectivity. This inexpensive and Pd and ligand free methodology gave rise to various isocoumarins of potential pharmacological interest.
引用
收藏
页码：9641 / 9644
页数：4
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