BCMA CAR T cells: the winding path to success

被引：11

作者：

Borrello, Ivan ^{[1
]}

Imus, Philip H. ^{[1
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Baltimore, MD USA

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2019年 / 129卷 / 06期

关键词：

MULTIPLE-MYELOMA; LYMPHOCYTES; REMISSIONS;

D O I：

10.1172/JCI128372

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Chimeric antigen receptor (CAR) T cells have been shown to successfully treat some hematopoietic malignancies. Recognition of a relevant target on malignant cells and the proper costimulatory molecule are essential for CAR T cell efficacy. In this issue of the JCI, Cohen et al. conducted an early phase trial to evaluate B cell maturation antigen-targeting (BCMA-targeting) CAR T cells in patients with refractory multiple myeloma. Patients who received the highest dose of BCMA-targeting CAR T cells in combination with lymphodepletion had the greatest response. The results of the study provide further support for the use of BCMA-targeting CAR T cells for myeloma, and reiterate the importance of space and cell dose for CAR T cell success.

引用

页码：2175 / 2177

页数：3

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