Role of intestinal microbiota in the formation of non-alcoholic fatty liver disease

被引：4
作者：
Akhmedov, V. A. [1 ]
Gaus, O., V [1 ]
机构：
[1] Omsk State Med Univ, Minist Hlth Russian Federat, Omsk, Russia
来源：
TERAPEVTICHESKII ARKHIV | 2019年 / 91卷 / 02期
关键词：
obesity; metabolic syndrome; non-alcoholic fatty liver disease; syndrome of excessive bacterial growth in the intestine; TRIMETHYLAMINE-N-OXIDE; TOLL-LIKE RECEPTOR-4; GUT MICROBIOTA; OXIDATIVE STRESS; OBESE-PATIENTS; PATHOGENESIS; ACID; PERMEABILITY; METABOLISM; ENDOTOXIN;
D O I：
10.26442/00403660.2019.02.000051
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The article provides an overview of modern views on the role of intestinal microbiota in the formation of non-alcoholic fatty liver disease. The general questions of the pathogenesis of the syndrome of excessive bacterial growth in the intestine, the participation of opportunistic microflora, the deficit of representatives of normal microflora, changes in the species composition of bile acids in the pathogenesis of nonalcoholic fatty liver disease are considered.
引用
收藏
页码：143 / 148
页数：6
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共 73 条
  • [1] Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation
    Arpaia, Nicholas
    Campbell, Clarissa
    Fan, Xiying
    Dikiy, Stanislav
    van der Veeken, Joris
    deRoos, Paul
    Liu, Hui
    Cross, Justin R.
    Pfeffer, Klaus
    Coffer, Paul J.
    Rudensky, Alexander Y.
    [J]. NATURE, 2013, 504 (7480) : 451 - +
  • [2] CD14 and toll-like receptor 4: a link between infection and acute coronary events?
    Arroyo-Espliguero, R
    Avanzas, P
    Jeffery, S
    Kaski, JC
    [J]. HEART, 2004, 90 (09) : 983 - 988
  • [3] The gut microbiota as an environmental factor that regulates fat storage
    Bäckhed, F
    Ding, H
    Wang, T
    Hooper, LV
    Koh, GY
    Nagy, A
    Semenkovich, CF
    Gordon, JI
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (44) : 15718 - 15723
  • [4] Mechanisms underlying the resistance to diet-induced obesity in germ-free mice
    Backhed, Fredrik
    Manchester, Jill K.
    Semenkovich, Clay F.
    Gordon, Jeffrey I.
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (03) : 979 - 984
  • [5] The Liver May Act as a Firewall Mediating Mutualism Between the Host and Its Gut Commensal Microbiota
    Balmer, Maria L.
    Slack, Emma
    de Gottardi, Andrea
    Lawson, Melissa A. E.
    Hapfelmeier, Siegfried
    Miele, Luca
    Grieco, Antonio
    Van Vlierberghe, Hans
    Fahrner, Rene
    Patuto, Nicola
    Bernsmeier, Christine
    Ronchi, Francesca
    Wyss, Madeleine
    Stroka, Deborah
    Dickgreber, Nina
    Heim, Markus H.
    Mccoy, Kathy D.
    Macpherson, Andrew J.
    [J]. SCIENCE TRANSLATIONAL MEDICINE, 2014, 6 (237)
  • [6] The epidemiology of non-alcoholic fatty liver disease
    Bellentani, Stefano
    [J]. LIVER INTERNATIONAL, 2017, 37 : 81 - 84
  • [7] Epidemiology of Non-Alcoholic Fatty Liver Disease
    Bellentani, Stefano
    Scaglioni, Federica
    Marino, Mariano
    Bedogni, Giorgio
    [J]. DIGESTIVE DISEASES, 2010, 28 (01) : 155 - 161
  • [8] Trimethylamine-N-Oxide, a Metabolite Associated with Atherosclerosis, Exhibits Complex Genetic and Dietary Regulation
    Bennett, Brian J.
    Vallim, Thomas Q. de Aguiar
    Wang, Zeneng
    Shih, Diana M.
    Meng, Yonghong
    Gregory, Jill
    Allayee, Hooman
    Lee, Richard
    Graham, Mark
    Crooke, Rosanne
    Edwards, Peter A.
    Hazen, Stanley L.
    Lusis, Aldons J.
    [J]. CELL METABOLISM, 2013, 17 (01) : 49 - 60
  • [9] How we detect microbes and respond to them: the Toll-like receptors and their transducers
    Beutler, B
    Hoebe, K
    Du, X
    Ulevitch, RJ
    [J]. JOURNAL OF LEUKOCYTE BIOLOGY, 2003, 74 (04) : 479 - 485
  • [10] The Severity of Nonalcoholic Fatty Liver Disease Is Associated With Gut Dysbiosis and Shift in the Metabolic Function of the Gut Microbiota
    Boursier, Jerome
    Mueller, Olaf
    Barret, Matthieu
    Machado, Mariana
    Fizanne, Lionel
    Araujo-Perez, Felix
    Guy, Cynthia D.
    Seed, Patrick C.
    Rawls, John F.
    David, Lawrence A.
    Hunault, Gilles
    Oberti, Frederic
    Cales, Paul
    Diehl, Anna Mae
    [J]. HEPATOLOGY, 2016, 63 (03) : 764 - 775
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