Role of intestinal microbiota in the formation of non-alcoholic fatty liver disease

被引：4

作者：

Akhmedov, V. A. ^{[1
]}

Gaus, O., V ^{[1
]}

机构：

[1] Omsk State Med Univ, Minist Hlth Russian Federat, Omsk, Russia

来源：

TERAPEVTICHESKII ARKHIV | 2019年 / 91卷 / 02期

关键词：

obesity; metabolic syndrome; non-alcoholic fatty liver disease; syndrome of excessive bacterial growth in the intestine; TRIMETHYLAMINE-N-OXIDE; TOLL-LIKE RECEPTOR-4; GUT MICROBIOTA; OXIDATIVE STRESS; OBESE-PATIENTS; PATHOGENESIS; ACID; PERMEABILITY; METABOLISM; ENDOTOXIN;

D O I：

10.26442/00403660.2019.02.000051

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The article provides an overview of modern views on the role of intestinal microbiota in the formation of non-alcoholic fatty liver disease. The general questions of the pathogenesis of the syndrome of excessive bacterial growth in the intestine, the participation of opportunistic microflora, the deficit of representatives of normal microflora, changes in the species composition of bile acids in the pathogenesis of nonalcoholic fatty liver disease are considered.

引用

页码：143 / 148

页数：6

共 73 条

[1] Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation [J].

Arpaia, Nicholas ;

Campbell, Clarissa ;

Fan, Xiying ;

Dikiy, Stanislav ;

van der Veeken, Joris ;

deRoos, Paul ;

Liu, Hui ;

Cross, Justin R. ;

Pfeffer, Klaus ;

Coffer, Paul J. ;

Rudensky, Alexander Y. .

NATURE, 2013, 504 (7480) :451-+

[2] CD14 and toll-like receptor 4: a link between infection and acute coronary events? [J].

Arroyo-Espliguero, R ;

Avanzas, P ;

Jeffery, S ;

Kaski, JC .

HEART, 2004, 90 (09) :983-988

[3] The gut microbiota as an environmental factor that regulates fat storage [J].

Bäckhed, F ;

Ding, H ;

Wang, T ;

Hooper, LV ;

Koh, GY ;

Nagy, A ;

Semenkovich, CF ;

Gordon, JI .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (44) :15718-15723

[4] Mechanisms underlying the resistance to diet-induced obesity in germ-free mice [J].

Backhed, Fredrik ;

Manchester, Jill K. ;

Semenkovich, Clay F. ;

Gordon, Jeffrey I. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (03) :979-984

[5] The Liver May Act as a Firewall Mediating Mutualism Between the Host and Its Gut Commensal Microbiota [J].

Balmer, Maria L. ;

Slack, Emma ;

de Gottardi, Andrea ;

Lawson, Melissa A. E. ;

Hapfelmeier, Siegfried ;

Miele, Luca ;

Grieco, Antonio ;

Van Vlierberghe, Hans ;

Fahrner, Rene ;

Patuto, Nicola ;

Bernsmeier, Christine ;

Ronchi, Francesca ;

Wyss, Madeleine ;

Stroka, Deborah ;

Dickgreber, Nina ;

Heim, Markus H. ;

Mccoy, Kathy D. ;

Macpherson, Andrew J. .

SCIENCE TRANSLATIONAL MEDICINE, 2014, 6 (237)

[6] The epidemiology of non-alcoholic fatty liver disease [J].

Bellentani, Stefano .

LIVER INTERNATIONAL, 2017, 37 :81-84

[7] Epidemiology of Non-Alcoholic Fatty Liver Disease [J].

Bellentani, Stefano ;

Scaglioni, Federica ;

Marino, Mariano ;

Bedogni, Giorgio .

DIGESTIVE DISEASES, 2010, 28 (01) :155-161

[8] Trimethylamine-N-Oxide, a Metabolite Associated with Atherosclerosis, Exhibits Complex Genetic and Dietary Regulation [J].

Bennett, Brian J. ;

Vallim, Thomas Q. de Aguiar ;

Wang, Zeneng ;

Shih, Diana M. ;

Meng, Yonghong ;

Gregory, Jill ;

Allayee, Hooman ;

Lee, Richard ;

Graham, Mark ;

Crooke, Rosanne ;

Edwards, Peter A. ;

Hazen, Stanley L. ;

Lusis, Aldons J. .

CELL METABOLISM, 2013, 17 (01) :49-60

[9] How we detect microbes and respond to them: the Toll-like receptors and their transducers [J].

Beutler, B ;

Hoebe, K ;

Du, X ;

Ulevitch, RJ .

JOURNAL OF LEUKOCYTE BIOLOGY, 2003, 74 (04) :479-485

[10] The Severity of Nonalcoholic Fatty Liver Disease Is Associated With Gut Dysbiosis and Shift in the Metabolic Function of the Gut Microbiota [J].

Boursier, Jerome ;

Mueller, Olaf ;

Barret, Matthieu ;

Machado, Mariana ;

Fizanne, Lionel ;

Araujo-Perez, Felix ;

Guy, Cynthia D. ;

Seed, Patrick C. ;

Rawls, John F. ;

David, Lawrence A. ;

Hunault, Gilles ;

Oberti, Frederic ;

Cales, Paul ;

Diehl, Anna Mae .

HEPATOLOGY, 2016, 63 (03) :764-775

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