Reorganisation of faecal microbiota transplant services during the COVID-19 pandemic

被引：121

作者：

Ianiro, Gianluca ^{[1
]}

Mullish, Benjamin H. ^{[2
]}

Kelly, Colleen R. ^{[3
]}

Kassam, Zain ^{[4
]}

Kuijper, Ed J. ^{[5
,6
]}

Ng, Siew C. ^{[7
]}

Iqbal, Tariq H. ^{[8
,9
]}

Allegretti, Jessica R. ^{[10
]}

Bibbo, Stefano ^{[1
]}

Sokol, Harry ^{[11
,12
,13
]}

Zhang, Faming ^{[14
]}

Fischer, Monika ^{[15
]}

Costello, Samuel Paul ^{[16
]}

Keller, Josbert J. ^{[6
,17
]}

Masucci, Luca ^{[18
]}

van Prehn, Joffrey ^{[6
]}

Quaranta, Gianluca ^{[18
]}

Quraishi, Mohammed Nabil ^{[8
,9
]}

Segal, Jonathan ^{[19
]}

Kao, Dina ^{[20
]}

Satokari, Reetta ^{[21
]}

Sanguinetti, Maurizio ^{[18
]}

Tilg, Herbert ^{[22
]}

Gasbarrini, Antonio ^{[1
]}

Cammarota, Giovanni ^{[1
]}

机构：

[1] Univ Cattolica Sacro Cuore, Fdn Policlin Univ A Gemelli IRCCS, Digest Dis Ctr, I-00168 Rome, Italy

[2] Imperial Coll London, Fac Med, Dept Metab Digest & Reprod, Div Digest Dis, London, England

[3] Brown Univ, Alpert Med Sch, Div Gastroenterol, Providence, RI 02912 USA

[4] Finch Therapeut Grp, Somerville, NJ USA

[5] Leiden Univ, Med Ctr, Dept Med Microbiol, Ctr Microbiota Anal & Therapy, Leiden, Netherlands

[6] Leiden Univ, Med Ctr, Netherlands Donor Feces Bank, Leiden, Netherlands

[7] Chinese Univ Hong Kong, Li Ka Shing Inst Hlth Sci, Inst Digest Dis,Dept Med & Therapeut, State Key Lab Digest Dis,Ctr Gut Microbiota Res, Hong Kong, Peoples R China

[8] Univ Birmingham, Microbiome Treatment Ctr, Birmingham, W Midlands, England

[9] Univ Hosp Birmingham NHS Fdn Trust, Dept Gastroenterol, Birmingham, W Midlands, England

[10] Harvard Med Sch, Brigham & Womens Hosp, Gastroenterol, Boston, MA 02115 USA

[11] Sorbonne Univ, Hop St Antoine, Serv Gastroenterol, INSERM,Ctr Rech St Antoine, Paris, France

[12] Sorbonne Univ, Hop St Antoine, French Grp Fecal Microbiota Transplantat, INSERM,Ctr Rech St Antoine, Paris, France

[13] AgroParisTech, INRA, UMR1319, Micalis, Jouy En Josas, France

[14] Nanjing Med Univ, Affiliated Hosp 2, Med Ctr Digest Dis, Nanjing, Peoples R China

[15] Indiana Univ, Dept Med, Indianapolis, IN USA

[16] Univ Adelaide, Dept Gastroenterol, Queen Elizabeth Hosp, Woodville, SA, Australia

[17] Haaglanden Med Ctr, Dept Gastroenterol, The Hague, Netherlands

[18] Univ Cattolica Sacro Cuore, Fdn Policlin Univ A Gemelli IRCCS, Inst Microbiol, Rome, Italy

[19] St Marks Hosp, Dept Gastroenterol, Harrow, Middx, England

[20] Univ Alberta, Dept Med, Div Gastroenterol, Edmonton, AB, Canada

[21] Univ Helsinki, Fac Med, Human Microbiome Res Program, Helsinki, Finland

[22] Innsbruck Med Univ, Dept Internal Med Gastroenterol Hepatol Endocrino, Innsbruck, Austria

来源：

GUT | 2020年 / 69卷 / 09期

关键词：

CLOSTRIDIUM-DIFFICILE INFECTION; SARS-COV-2; DONORS; STOOL; VANCOMYCIN; PROTOCOL; BURDEN;

D O I：

10.1136/gutjnl-2020-321829

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

The COVID-19 pandemic has led to an exponential increase in SARS-CoV-2 infections and associated deaths, and represents a significant challenge to healthcare professionals and facilities. Individual countries have taken several prevention and containment actions to control the spread of infection, including measures to guarantee safety of both healthcare professionals and patients who are at increased risk of infection from COVID-19. Faecal microbiota transplantation (FMT) has a well-established role in the treatment of Clostridioides difficile infection. In the time of the pandemic, FMT centres and stool banks are required to adopt a workflow that continues to ensure reliable patient access to FMT while maintaining safety and quality of procedures. In this position paper, based on the best available evidence, worldwide FMT experts provide guidance on issues relating to the impact of COVID-19 on FMT, including patient selection, donor recruitment and selection, stool manufacturing, FMT procedures, patient follow-up and research activities.

引用

页码：1555 / 1563

页数：9

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