A case of semantic variant primary progressive aphasia with severe insular atrophy

被引：6

作者：

Chow, T. W. ^{[1
,2
,3
]}

Links, K. A. ^{[1
]}

Masterman, D. L. ^{[4
]}

Mendez, M. F.

Vinters, H. V. ^{[5
,6
,7
]}

机构：

[1] Baycrest Rotman Res Inst, Toronto, ON, Canada

[2] Univ Toronto, Dept Med, Div Neurol, Toronto, ON, Canada

[3] Univ Toronto, Dept Psychiat, Div Geriatr Psychiat, Toronto, ON, Canada

[4] Genentech Inc, Los Angeles, CA USA

[5] Univ Calif Los Angeles, Dept Pathol & Lab Med, Los Angeles, CA USA

[6] Univ Calif Los Angeles, Dept Neurol, Los Angeles, CA 90024 USA

[7] Mary Easton Alzheimer Dis Res Ctr, Los Angeles, CA USA

来源：

NEUROCASE | 2012年 / 18卷 / 06期

关键词：

Frontotemporal dementia; MRI; PET; SPECT; Insula; FRONTOTEMPORAL DEMENTIA; PICKS-DISEASE; PATTERNS;

D O I：

10.1080/13554794.2011.627343

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Insular degeneration has been linked to symptoms of frontotemporal dementia (FTD). Presented in this case is a patient exhibiting semantic variant primary progressive aphasia, behavioral disturbance. Upon autopsy, he was found to have severe insular atrophy. In addition, selective serotonin reuptake inhibitors were ineffective in reducing symptoms of obsessive-compulsive behaviors or emotional blunting. This case suggests that Seeley et al.'s (2007, Alzheimer Disease & Associated Disorders, 21, S50) hypothesis that von Economo neurons and fork cell-rich brain regions, particularly in the insula, are targeted in additional subtypes of FTD beyond the behavioral variant.

引用

页码：450 / 456

页数：7

共 23 条

[1] Escitalopram effects on insula and amygdala BOLD activation during emotional processing [J].