Trichloroethylene induced testicular toxicity in rats exposed by inhalation

被引：13
作者：
Kumar, P [1 ]
Prasad, AK [1 ]
Mani, U [1 ]
Maji, BK [1 ]
Dutta, KK [1 ]
机构：
[1] Ind Toxicol Res Ctr, Inhalat Toxicol Div & Anim House, Lucknow 226001, Uttar Pradesh, India
来源：
HUMAN & EXPERIMENTAL TOXICOLOGY | 2001年 / 20卷 / 11期
关键词：
trichloroethylene; inhalation; testis; rat;
D O I：
10.1191/096032701718620882
中图分类号：
R99 [毒物学（毒理学）];
学科分类号：
100405 ;
摘要：
Trichloroethylene (TCE) is an organic solvent used in dry cleaning, metal degreasing, thinner for paints and varnishes, anesthetic agent, and so forth. Human beings are appreciably exposed to TCE vapours by inhalation route. The present study has been undertaken to investigate whether TCE inhalation may also bring about testicular toxic effects. Our results indicate that inhalation of TCE by male rats for 12 and 24 weeks brings about significant reduction in absolute testicular weight, and alters marker testicular enzymes activity associated with spermatogenesis and germ cell maturation, along with marked histopathological changes showing depletion of germs cells and spermatogenic arrest.
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收藏
页码：585 / 589
页数：5
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