Tracing the origin of Brazilian HTLV-1 as determined by analysis of host and viral genes

被引：23

作者：

Alcantara, LCJ ^{[1
]}

de Oliveira, T

Gordon, M

Pybus, O

Mascarenhas, RE

Seixas, MO

Gonçalves, M

Hlela, C

Cassol, S

Galvao-Castro, B

机构：

[1] Oswaldo Cruz Fdn, Goncalo Moniz Res Ctr, Publ Hlth Adv Lab, Salvador, BA, Brazil

[2] Bahia Sch Med & Publ Hlth Fdn Sci Dev, Salvador, BA, Brazil

[3] Univ KwaZulu Natal, Nelson Mandela Med Sch, Africa Ctr Hlth & Populat Studies, Mol Virol & Bioinformat Unit, Durban, South Africa

[4] Univ Oxford, Dept Zool, Oxford, England

[5] Oswaldo Cruz Fdn, Goncalo Moniz Res Ctr, Mol Biol & Pathol Lab, Salvador, BA, Brazil

[6] Univ Pretoria, Dept Virol, Immunopathogenesis Unit HIV1, ZA-0002 Pretoria, South Africa

来源：

AIDS | 2006年 / 20卷 / 05期

关键词：

D O I：

10.1097/01.aids.0000216383.14808.13

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We compared the genetic diversity of the Brazilian human T-cell lymphotropic virus type 1 isolates with those found in KwaZulu-Natal (KZN), South Africa, and with the genetic background of the hosts. The seroprevalence rate in KZN was 1.7%. All sequences belonged to the A subgroup. The presence of South African sequences in two different clusters from Brazil, and the finding of the beta(A)-globin haplotype in infected hosts are consistent with the transmission of this virus from southern Africa to Brazil.

引用

页码：780 / 782

页数：3

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