Enantioselective Decarboxylative Amination: Synthesis of Axially Chiral Allenyl Amines

被引：82
|
作者：
Wan, Baoqiang [1 ]
Ma, Shengming [1 ,2 ]
机构：
[1] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China
[2] E China Normal Univ, Dept Chem, Shanghai Key Lab Green Chem & Chem Proc, Shanghai 200062, Peoples R China
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2013年 / 52卷 / 01期
基金：
中国国家自然科学基金;
关键词：
allene; amination; chirality; enantioselectivity; synthetic methods; CATALYZED ASYMMETRIC-SYNTHESIS; ALLYLIC ALKYLATION; GOLD CATALYSIS; ZINC ENOLATE; OPPORTUNITIES; CYCLOADDITION; PHOSPHATES; CHEMISTRY; METALS; ESTERS;
D O I：
10.1002/anie.201204796
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Getting axed: Synthesis of the title amines, bearing functionality (R 1 and R2), involves the enantioselective palladiumcatalyzed decarboxylation of allenyl Ntosylcarbamates. The reaction proceeds smoothly using both the chiral ligands (S)- and (R)-DTBM-Segphos (1) to afford the allenyl amines in good yields and with high enantioseletivities. © 2013 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：441 / 445
页数：5
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