Involvement of Interleukin 6 in Hepatitis B Viral Infection

被引：51

作者：

Xia, Caixia ^{[1
]}

Liu, Yanning ^{[1
]}

Chen, Zhi ^{[1
]}

Zheng, Min ^{[1
]}

机构：

[1] Zhejiang Univ, Collaborat Innovat Ctr Diag & Treatment Infect Di, State Key Lab Diag & Treatment Infect Dis, Affiliated Hosp 1,Sch Med, Hangzhou 310003, Zhejiang, Peoples R China

来源：

CELLULAR PHYSIOLOGY AND BIOCHEMISTRY | 2015年 / 37卷 / 02期

基金：

中国国家自然科学基金;

关键词：

Interleukin; 6; Hepatitis B; HBx; SNP; CHINESE HAN POPULATION; NF-KAPPA-B; VIRUS-INFECTION; HEPATOCELLULAR-CARCINOMA; GENETIC-POLYMORPHISM; POOR-PROGNOSIS; LIVER-CANCER; EXPRESSION; IL-6; PROTEIN;

D O I：

10.1159/000430386

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Hepatitis B is a major global health problem and a potentially life-threatening liver infection caused by hepatitis B virus (HBV). Many cytokines including interleukin 6 (IL-6) have been shown to be involved in the HBV infection process. IL-6 is a typical cytokine made up of 184 amino acids, and the gene is located in chromosome 7p21. For healthy people, serum IL-6 levels are usually too low to be detected. However, dysregulated synthesis of IL-6 has been discovered in chronic inflammatory diseases such as hepatitis B, Crohn's disease and rheumatoid arthritis. IL-6 also plays an important role in HBV replication and in the development of hepatitis B disease. This review aims to present the latest discoveries concerning the role of IL-6 in hepatitis B disease progression, and HBV entry and replication, and evaluate polymorphisms that are associated with the development of hepatitis B disease. Copyright (C) 2015 S. Karger AG, Basel

引用

页码：677 / 686

页数：10

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