Cyclodextrin complexation highly enhances efficacy of arylsulfonylureido benzenesulfonamide carbonic anhydrase inhibitors as a topical antiglaucoma agents

被引：10
作者：
Bragagni, Marco [1 ]
Bozdag, Murat [2 ]
Carta, Fabrizio [2 ]
Scozzafava, Andrea [2 ]
Lanzi, Cecilia [3 ]
Masini, Emanuela [3 ]
Mura, Paola [1 ]
Supuran, Claudiu T. [4 ]
机构：
[1] Univ Florence, Dipartimento Chim, I-50019 Florence, Italy
[2] Univ Florence, Dipartimento Chim, Lab Chim Bioinorgan, I-50019 Florence, Italy
[3] Univ Florence, Dipartimento NEUROFARBA, Sez Farmacol, I-50139 Florence, Italy
[4] Univ Florence, Dipartimento NEUROFARBA, Sez Sci Farmaceut & Nutraceut, I-50019 Florence, Italy
来源：
BIOORGANIC & MEDICINAL CHEMISTRY | 2015年 / 23卷 / 18期
关键词：
Sulfonamide; Carbonic anhydrase; Isoforms I; II; IX; XII; Antiglaucoma agent; Cyclodextrin complexation; SULFONAMIDES; MECHANISM; DELIVERY; DRUGS; STATE; TAIL; QSAR;
D O I：
10.1016/j.bmc.2015.07.047
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Two new sulfonamides incorporating arylsulfonylureido moieties were complexed with gamma cyclodextrin (gamma-CD), hydroxypropyl-gamma cyclodextrin (HP gamma-CD), hydroxypropyl-beta cyclodextrin (HP beta-CD) and hydroxyethyl-beta cyclodextrin (HE beta-CD) in order to obtain drug formulations with effective topical intraocular pressure (IOP) lowering effects, in an animal model of glaucoma. The HP gamma-CD was the best solubilizing agent for the two sulfonamides and its complexes were characterized in detail and administered to rabbits with eye hypertension of 45-50 mm Hg. The peak IOP lowering was observed after 1 h post-administration and was of 36-37 mm Hg. A low IOP pressure (of around-35 mm Hg) was then maintained for the next 24 h post-administration, which has not been observed before with any IOP lowering drug. (c) 2015 Elsevier Ltd. All rights reserved.
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收藏
页码：6223 / 6227
页数：5
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