Development and efficient 1-glycyl-3-methyl imidazolium chloride-copper(II) complex catalyzed highly enantioselective synthesis of 3, 4-dihydropyrimidin-2(1H)-ones

A novel, effective asymmetric 1-glycyl-3-methyl imidazolium chloride-copper(II) complex [[Gmim]Cl-Cu(II)] was synthesized and studied as organocatalyst for enantioselective Biginelli reaction under solvent free condition at 25 degrees C. The hydrophobic group on amino acid favors reagent diffusion towards the chloroglycine moiety increasing the catalytic activity of supported palladium complex. Spectroscopic evidence of complex has been proved by Powder XRD, SEM, FT-IR and AFM. This method contains simplified product isolation and catalyst recycling, affording substituted aldehydes imparting high yield with excellent stereoselectivity. This recyclable heterogeneous catalyst provides a simple strategy for the generation of a variety of new C-C bonds under environmentally benign condition. (C) 2012 Published by Elsevier B.V.