An overview of the multifaceted roles of miRNAs in gastric cancer: Spotlight on novel biomarkers and therapeutic targets

被引：18

作者：

Wu, Xu ^{[1
,2
]}

Shen, Jing ^{[1
,2
]}

Xiao, Zhangang ^{[1
,2
]}

Li, Jing ^{[3
]}

Zhao, Yueshui ^{[1
,2
]}

Zhao, Qijie ^{[1
,2
]}

Cho, Chi Hin ^{[1
,2
]}

Li, Mingxing ^{[1
,2
]}

机构：

[1] Southwest Med Univ, Sch Pharm, Dept Pharmacol, Mol Pharmacol Lab, Luzhou 646000, Sichuan, Peoples R China

[2] South Sichuan Inst Translat Med, Luzhou 646000, Sichuan, Peoples R China

[3] Southwest Med Univ, Hosp TCM, Dept Hematol & Oncol, Luzhou 646000, Sichuan, Peoples R China

来源：

BIOCHEMICAL PHARMACOLOGY | 2019年 / 163卷

基金：

中国国家自然科学基金;

关键词：

miRNA; Gastric cancer; Therapeutic targets; Drug resistance; REGULATES MULTIDRUG-RESISTANCE; EPITHELIAL-MESENCHYMAL TRANSITION; HELICOBACTER-PYLORI; CELL-PROLIFERATION; CLUSTERED MICRORNAS; NEGATIVE REGULATION; SIGNALING PATHWAY; SYSTEMIC DELIVERY; DOWN-REGULATION; EXPRESSION;

D O I：

10.1016/j.bcp.2019.03.011

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

MicroRNAs (miRNAs) are a group of small non-coding RNAs that have displayed strong association with gastric cancer (GC). Through the repression of target mRNAs, miRNAs regulate many biological pathways that are involved in cell proliferation, apoptosis, migration, invasion, metastasis as well as drug resistance. The detection of miRNAs in tissues and in body fluids emerges as a promising method in the diagnosis and prognosis of GC, due to their unique expression pattern in correlation with GC. Notably, miRNAs are also identified as potential therapeutic targets for GC therapy. The present review is thus to highlight the multifaceted roles of miRNAs in GC and in GC therapies, which would give indications for future research.

引用

页码：425 / 439

页数：15

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