Regulatory B and T cells in infections

被引：48
|
作者：
Majlessi, Laleh [1 ,2 ]
Lo-Man, Richard [1 ,2 ]
Leclerc, Claude [1 ,2 ]
机构：
[1] Inst Pasteur, Unite Regulat Immunitaire & Vaccinol, F-75724 Paris 15, France
[2] Inst Natl Sante & Rech Med, U883, F-75724 Paris 15, France
来源：
MICROBES AND INFECTION | 2008年 / 10卷 / 09期
关键词：
Regulatory B and T; Infections; Immune modulation;
D O I：
10.1016/j.micinf.2008.07.017
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The role of T and B lymphocytes, as antigen-specific effector immune cells playing an essential role in host defense against pathogens. is well recognized. Over the last decade, these lymphocytes have however also emerged as key regulatory components of the immune system,, able to prevent various immunopathologies due to excessive inflammatory responses. These regulatory T (Treg) and B (Breg) cells. endowed with anti-inflammatory properties, operate via both antigen-specific and non-specific mechanisms and mainly develop during chronic infections. Here, we discuss the role of Treg and Breg lymphocytes in various infectious diseases, in experimental murine models and in human. (C) 2008 Elsevier Masson SAS. All rights reserved.
引用
收藏
页码：1030 / 1035
页数：6
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