Exercise training increases the stability of atherosclerotic plaques in apolipoprotein E (ApoE) gene-deficient mice

被引：0

作者：

Zhang, Xu ^{[1
]}

Shao, Shi-Xiu ^{[2
]}

Zheng, Xue-Ping ^{[1
]}

Zhao, Ren-Liang ^{[1
]}

Gao, Xiang ^{[1
]}

机构：

[1] Qingdao Univ, Affiliated Hosp, Dept Neurol, Qingdao 266000, Peoples R China

[2] Qingdao Univ, Affiliated Hosp, Dept Urol, Qingdao 266000, Peoples R China

来源：

INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE | 2016年 / 9卷 / 07期

关键词：

Atherosclerosis; exercise; apolipoprotein E gene deficient mice; RUPTURE; RISK; MATRIX-METALLOPROTEINASE-9; PROGRESSION; MECHANISMS; SEVERITY; MATRIX; MOUSE;

D O I：

暂无

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The aim of this study was to investigate the effect of exercise training on the stability of atherosclerotic plaques in apolipoprotein E (ApoE) gene-deficient mice. A total of 80 ApoE gene-deficient mice were randomly divided into exercise and control groups. The exercise group was subjected to 8 weeks of electric treadmill training, while the activity of animals in the control group was restricted for the same 8-week period. In the exercise group the thickness of the fibrous cap was significantly increased (P < 0.05), and plaque stability was also increased. The plaque vulnerability index of the exercise group exhibited a significant difference compared to the control group (P < 0.05). The expression of matrix metalloproteinase-9 (MMP-9) and MMP-14 was significantly lower in plaques from the exercise group (P < 0.05), while blood lipid levels and plaque area showed no significant difference between the two groups (P > 0.05). These data suggest that exercise could increase the stability of atherosclerotic plaques, and therefore delay the progression of atherosclerosis.

引用

页码：13820 / 13827

页数：8

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