Regulatory B cells: the cutting edge of immune tolerance in kidney transplantation

被引：82
作者：
Peng, Bo [1 ]
Ming, Yingzi [1 ]
Yang, Cheng [2 ,3 ]
机构：
[1] Cent South Univ, Xiangya Hosp 3, Transplantat Ctr, Changsha 410013, Hunan, Peoples R China
[2] Zhongshan Hosp, Dept Urol, Shanghai 200032, Peoples R China
[3] Fudan Univ, Shanghai Key Lab Organ Transplantat, Shanghai 200032, Peoples R China
来源：
CELL DEATH & DISEASE | 2018年 / 9卷
基金：
中国国家自然科学基金;
关键词：
B10; CELLS; MURINE MODEL; T-CELLS; RENAL-TRANSPLANTATION; ALEMTUZUMAB INDUCTION; SUPPRESSOR-CELLS; RANDOMIZED-TRIAL; IL-10; PRODUCTION; TGF-BETA; AUTOIMMUNE;
D O I：
10.1038/s41419-017-0152-y
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Kidney transplantation is the optimal treatment for end-stage renal diseases. Although great improvement has been achieved, immune tolerance is still the Holy Grail that every organ transplant practitioner pursues. The role of B cells in transplantation has long been considered simply to serve as precursors of plasma cells, which produce alloantibodies and induce antibody-mediated rejection. Recent research indicates that a specialized subset of B cells plays an important role in immune regulation, which has been well demonstrated in autoimmune diseases, infections, and cancers. This category of regulatory B cells (Bregs) differs from conventional B cells, and they may help develop a novel immunomodulatory therapeutic strategy to achieve immune tolerance in transplantation. Here, we review the latest evidence regarding phenotypes, functions, and effectors of Bregs and discuss their diverse effects on kidney transplantation.
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页数：13
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共 107 条
  • [1] TIM-1 defines a human regulatory B cell population that is altered in frequency and function in systemic sclerosis patients
    Aravena, Octavio
    Ferrier, Ashley
    Menon, Madhvi
    Mauri, Claudia
    Aguillon, Juan Carlos
    Soto, Lilian
    Catalan, Diego
    [J]. ARTHRITIS RESEARCH & THERAPY, 2017, 19
  • [2] B Cell Receptor Genes Associated With Tolerance Identify a Cohort of Immunosuppressed Patients With Improved Renal Allograft Graft Function
    Asare, A.
    Kanaparthi, S.
    Lim, N.
    Phippard, D.
    Vincenti, F.
    Friedewald, J.
    Pavlakis, M.
    Poggio, E.
    Heeger, P.
    Mannon, R.
    Burrell, B. E.
    Morrison, Y.
    Bridges, N.
    Sanz, I.
    Chandraker, A.
    Newell, K. A.
    Turka, L. A.
    [J]. AMERICAN JOURNAL OF TRANSPLANTATION, 2017, 17 (10) : 2627 - 2639
  • [3] Could Osteoprotegerin and TNF-Related Apoptosis-Inducing Ligand Assessments Help Us to Manage Early Rheumatoid Arthritis? Results from the Espoir Cohort
    Audo, Rachel
    Daien, Claire I.
    Papon, Laura
    Lukas, Cedric
    Vittecoq, O.
    Combe, B.
    Morel, Jacques
    [J]. ARTHRITIS & RHEUMATOLOGY, 2014, 66 : S168 - S169
  • [4] Marginal Zone B Cells Regulate Antigen-Specific T Cell Responses during Infection
    Bankoti, Rashmi
    Gupta, Kshitiz
    Levchenko, Andre
    Staeger, Simona
    [J]. JOURNAL OF IMMUNOLOGY, 2012, 188 (08) : 3961 - 3971
  • [5] B cell-derived transforming growth factor-β1 expression limits the induction phase of autoimmune neuroinflammation
    Bjarnadottir, Kristbjorg
    Benkhoucha, Mahdia
    Merkler, Doron
    Weber, Martin S.
    Payne, Natalie L.
    Bernard, Claude C. A.
    Molnarfi, Nicolas
    Lalive, Patrice H.
    [J]. SCIENTIFIC REPORTS, 2016, 6
  • [6] CD19+CD24hiCD38hi B Cells Exhibit Regulatory Capacity in Healthy Individuals but Are Functionally Impaired in Systemic Lupus Erythematosus Patients
    Blair, Paul A.
    Norena, Lina Yassin
    Flores-Borja, Fabian
    Rawlings, David J.
    Isenberg, David A.
    Ehrenstein, Michael R.
    Mauri, Claudia
    [J]. IMMUNITY, 2010, 32 (01) : 129 - 140
  • [7] Selective Targeting of B Cells with Agonistic Anti-CD40 Is an Efficacious Strategy for the Generation of Induced Regulatory T2-Like B Cells and for the Suppression of Lupus in MRL/lpr Mice
    Blair, Paul A.
    Chavez-Rueda, Karina A.
    Evans, Jamie G.
    Shlomchik, Mark J.
    Eddaoudi, Ayad
    Isenberg, David A.
    Ehrenstein, Michael R.
    Mauri, Claudia
    [J]. JOURNAL OF IMMUNOLOGY, 2009, 182 (06) : 3492 - 3502
  • [8] Bodhankar S., 2013, J CLIN CELL IMMUNOL, V4, P143, DOI DOI 10.4172/2155-9899.1000143
  • [9] Tolerance in Kidney Transplantation: What Is on the B Side?
    Carreras-Planella, Laura
    Borras, Francesc E.
    Franquesa, Marcella
    [J]. MEDIATORS OF INFLAMMATION, 2016, 2016
  • [10] Mice Lacking Endogenous IL-10-Producing Regulatory B Cells Develop Exacerbated Disease and Present with an Increased Frequency of Th1/Th17 but a Decrease in Regulatory T Cells
    Carter, Natalie A.
    Vasconcellos, Rita
    Rosser, Elizabeth C.
    Tulone, Calogero
    Munoz-Suano, Alba
    Kamanaka, Masahito
    Ehrenstein, Michael R.
    Flavell, Richard A.
    Mauri, Claudia
    [J]. JOURNAL OF IMMUNOLOGY, 2011, 186 (10) : 5569 - 5579
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