Alginate beads as a carrier for omeprazole/SBA-15 inclusion compound: A step towards the development of personalized paediatric dosage forms

被引：21
作者：
Del Gaudio, Pasquale [1 ]
De Cicco, Felicetta [1 ]
Sansone, Francesca [1 ]
Aquino, Rita Patrizia [1 ]
Adami, Renata [2 ]
Ricci, Maurizio [3 ]
Giovagnoli, Stefano [3 ]
机构：
[1] Univ Salerno, Dept Pharm, I-84084 Fisciano, SA, Italy
[2] Univ Salerno, Dept Ind Engn, I-84084 Fisciano, SA, Italy
[3] Univ Perugia, Dept Pharmaceut Sci, I-06123 Perugia, Italy
来源：
CARBOHYDRATE POLYMERS | 2015年 / 133卷
关键词：
Alginate beads; Omeprazole; Paediatric formulations; Prilling; SBA-15; Enteric particles; PROTON PUMP INHIBITORS; DRUG-DELIVERY; MESOPOROUS SILICA; RELEASE; PHARMACOKINETICS; MICROPARTICLES; TECHNOLOGIES; CHILDREN; INFANTS;
D O I：
10.1016/j.carbpol.2015.07.064
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
The treatment of gastro-esophageal reflux disease (GERD) shows several issues among paediatric patients. This work aims to the formulation of enteric alginate beads loaded with omeprazole (OME) allowing age- and weight-related personalized dosages in children. OME was entrapped in SBA-15 mesoporous compound, characterized and loaded into alginate beads by prilling at different OME and alginate concentrations. The beads resulted of homogeneous size, spherical morphology and very consistent in drug loading and distribution. Formulations demonstrated limited swelling and release (about 10%) in simulated gastric fluid (SGF) after 2 h and a prolonged release in simulated intestinal fluid (SIF), till 6 h, due to a mixed diffusion-case II transport mechanism. The beads were superior to the market product, which showed lower release in SGF but immediate dissolution in SIF. The high alginate beads uniformity and release properties make them a potential novel tool for a personalized treatment of GERD in children. (C) 2015 Elsevier Ltd. All rights reserved.
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收藏
页码：464 / 472
页数：9
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