Metal-Free, Acid-Catalyzed ortho-Directed Synthesis of Anthranilic Acid Derivatives Using Carbodiimides

被引：9

作者：

Culf, Adrian S. ^{[1
]}

Cuperlovic-Culf, Miroslava ^{[2
]}

Ouellette, Rodney J. ^{[1
]}

Decken, Andreas ^{[3
]}

机构：

[1] Atlantic Canc Res Inst, Moncton, NB E1C 8X3, Canada

[2] Natl Res Council Canada, Moncton, NB E1A 7R1, Canada

[3] Univ New Brunswick, Dept Chem, Fredericton, NB E3B 5A3, Canada

来源：

ORGANIC LETTERS | 2015年 / 17卷 / 11期

关键词：

CROSS-COUPLING REACTIONS; O-AMINOBENZOATES; BENZOIC-ACIDS; CARBONYLATION; AMINATION; FUNCTIONALIZATION; OPTIMIZATION; FLUORINATION; ACTIVATION; COMPLEXITY;

D O I：

10.1021/acs.orglett.5b01160

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

One-pot syntheses of fluorescent o-aminobenzoates, o-aminopyridine carboxylates, and a 2'-amino-[1,1'-biphenyl]-2-carboxylic acid are described. Carbodiimides are used as the source of the 2-amino function which inserts onto an aromatic ring using SNAr reaction conditions. This method proceeds regiospecifically with a range of 2-fluoroaromatic acids or esters bearing further aryl fluorine, trifluoromethyl, and cyano substituents.

引用

页码：2744 / 2747

页数：4

共 43 条

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