Transcriptional regulation of the insulin-responsive glucose transporter GLUT4 gene: from physiology to pathology

被引：95

作者：

Karnieli, Eddy ^{[1
]}

Armoni, Michal

机构：

[1] Rambam Med Ctr, Inst Endocrinol Diabet & Metab, IL-31096 Haifa, Israel

来源：

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM | 2008年 / 295卷 / 01期

关键词：

adipose; diabetes; gene expression; muscle; obesity; peroxisome proliferator-activated receptor-gamma; forkhead box O1;

D O I：

10.1152/ajpendo.90306.2008

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The insulin-responsive glucose transporter 4 (GLUT4) plays a key role in glucose uptake and metabolism in insulin target tissues. Being a rate-limiting step in glucose metabolism, the expression and function of the GLUT4 isoform has been extensively studied and found to be tightly regulated at both mRNA and protein levels. Adaptation to states of enhanced metabolic demand is associated with increased glucose metabolism and GLUT4 gene expression, whereas states of insulin resistance such as type 2 diabetes mellitus (DM2), obesity, and aging are associated with impaired regulation of GLUT4 gene expression and function. The present review focuses on the interplay among hormonal, nutritional, and transcription factors in the regulation of GLUT4 transcription in health and sickness.

引用

页码：E38 / E45

页数：8

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