Implication of Conjugated Linoleic Acid (CLA) in Human Health

被引：300

作者：

Dilzer, Allison ^{[1
]}

Park, Yeonhwa ^{[1
]}

机构：

[1] Univ Massachusetts, Dept Food Sci, Amherst, MA 01003 USA

来源：

CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION | 2012年 / 52卷 / 06期

关键词：

conjugated linoleic acid; CLA; trans fatty acids; obesity; cardiovascular diseases; cancer; bone; BODY-FAT MASS; TRANSEPITHELIAL CALCIUM-TRANSPORT; C-REACTIVE PROTEIN; MODERATELY OVERWEIGHT SUBJECTS; POSTMENOPAUSAL BREAST-CANCER; RATS FED N-6; LIPID-PEROXIDATION; ADIPOSE-TISSUE; INSULIN SENSITIVITY; DIETARY SUPPLEMENTATION;

D O I：

10.1080/10408398.2010.501409

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Conjugated linoleic acid (CLA) has drawn significant attention in the last two decades for its variety of biologically beneficial effects. CLA reduces body fat, cardiovascular diseases and cancer, and modulates immune and inflammatory responses as well as improves bone mass. It has been suggested that the overall effects of CLA are the results of interactions between two major isomers, cis-9,trans-11 and trans-10,cis-12. This review will primarily focus on current CLA publications involving humans, which are also summarized in the tables. Along with a number of beneficial effects of CLA, there are safety considerations for CLA supplementation in humans, which include effects on liver functions, milk fat depression, glucose metabolism, and oxidative stresses.

引用

页码：488 / 513

页数：26

共 186 条

[11] Colonic anti-inflammatory mechanisms of conjugated linoleic acid [J].

Bassaganya-Riera, J ;

Hontecillas, R ;

Beitz, DC .

CLINICAL NUTRITION, 2002, 21 (06) :451-459

[12]

Basu S, 2000, CLIN SCI, V99, P511, DOI [10.1042/CS20000116, 10.1042/cs0990511]

[13] Conjugated linoleic acid induces lipid peroxidation in humans [J].

Basu, S ;

Smedman, A ;

Vessby, B .

FEBS LETTERS, 2000, 468 (01) :33-36

[14] Conjugated linoleic acid modulates hepatic lipid composition in mice [J].

Belury, MA ;

KempaSteczko, A .

LIPIDS, 1997, 32 (02) :199-204

[15] The conjugated linoleic acid (CLA) isomer, t10c12-CLA, is inversely associated with changes in body weight and serum leptin in subjects with type 2 diabetes mellitus [J].

Belury, MA ;

Mahon, A ;

Banni, S .

JOURNAL OF NUTRITION, 2003, 133 (01) :257S-260S

[16] The effect of conjugated linoleic acid on plasma lipoproteins and tissue fatty acid composition in humans [J].

Benito, P ;

Nelson, GJ ;

Kelley, DS ;

Bartolini, G ;

Schmidt, PC ;

Simon, V .

LIPIDS, 2001, 36 (03) :229-236

[17] The effect of conjugated linoleic acid on platelet function, platelet fatty acid composition, and blood coagulation in humans [J].

Benito, P ;

Nelson, GJ ;

Kelley, DS ;

Bartolini, G ;

Schmidt, PC ;

Simon, V .

LIPIDS, 2001, 36 (03) :221-227

[18] Potent inhibitory effect of trans9, trans 11 isomer of conjugated linoleic acid on the growth of human colon cancer cells [J].

Beppu, Fumiaki ;

Hosokawa, Masashi ;

Tanaka, Leo ;

Kohno, Hiroyuki ;

Tanaka, Takuji ;

Miyashita, Kazuo .

JOURNAL OF NUTRITIONAL BIOCHEMISTRY, 2006, 17 (12) :830-836

[19] Conjugated linoleic acid in diets for juvenile Atlantic salmon (Salmo salar);: effects on fish performance, proximate composition, fatty acid and mineral content [J].

Berge, GM ;

Ruyter, B ;

Åsgård, T .

AQUACULTURE, 2004, 237 (1-4) :365-380

[20]

Berven G, 2000, EUR J LIPID SCI TECH, V102, P455, DOI 10.1002/1438-9312(200008)102:7<455::AID-EJLT455>3.0.CO

← 1 2 3 4 5 6 7 8 9 10 →