Will SNPs be useful predictors of normal tissue radiosensitivity in the future?

被引：19

作者：

Andreassen, Christian Nicolaj ^{[1
]}

Dikomey, Ekkehard ^{[2
]}

Parliament, Matthew ^{[3
]}

West, Catharine Mary Louise ^{[4
]}

机构：

[1] Aarhus Univ Hosp, Dept Oncol, DK-8000 Aarhus C, Denmark

[2] Univ Med Ctr Hamburg Eppendorf, Hamburg, Germany

[3] Cross Canc Inst, Edmonton, AB T6G 1Z2, Canada

[4] Inst Canc Sci, Manchester, Lancs, England

来源：

RADIOTHERAPY AND ONCOLOGY | 2012年 / 105卷 / 03期

关键词：

Normal tissue radiosensitivity; Genetics; Single nucleotide polymorphisms; GENOME-WIDE ASSOCIATION; BREAST-CANCER PATIENTS; RADIOTHERAPY TOXICITY; BLOOD-LYMPHOCYTES; NO ASSOCIATION; SKIN REACTIONS; DNA; RISK; POLYMORPHISMS; VARIANTS;

D O I：

10.1016/j.radonc.2012.11.003

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The ability to predict individual risk of radiation-induced normal tissue complications is a long sought goal in radiobiology. The last decade saw increasing interest in identifying associations between single nucleotide polymorphisms (SNPs) and normal tissue complication risk. Nevertheless, it remains controversial whether SNPs will be useful predictors of normal tissue radiosensitivity. This paper provides a summary of a scientific debate held at the 31st ESTRO conference in which four scientists argued in favor or against the motion that SNPs will be useful predictors of normal tissue radiosensitivity in the future. (C) 2012 Elsevier Ireland Ltd. All rights reserved. Radiotherapy and Oncology 105 (2012) 283-288

引用

页码：283 / 288

页数：6

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