Will SNPs be useful predictors of normal tissue radiosensitivity in the future?

被引：19

作者：

Andreassen, Christian Nicolaj ^{[1
]}

Dikomey, Ekkehard ^{[2
]}

Parliament, Matthew ^{[3
]}

West, Catharine Mary Louise ^{[4
]}

机构：

[1] Aarhus Univ Hosp, Dept Oncol, DK-8000 Aarhus C, Denmark

[2] Univ Med Ctr Hamburg Eppendorf, Hamburg, Germany

[3] Cross Canc Inst, Edmonton, AB T6G 1Z2, Canada

[4] Inst Canc Sci, Manchester, Lancs, England

来源：

RADIOTHERAPY AND ONCOLOGY | 2012年 / 105卷 / 03期

关键词：

Normal tissue radiosensitivity; Genetics; Single nucleotide polymorphisms; GENOME-WIDE ASSOCIATION; BREAST-CANCER PATIENTS; RADIOTHERAPY TOXICITY; BLOOD-LYMPHOCYTES; NO ASSOCIATION; SKIN REACTIONS; DNA; RISK; POLYMORPHISMS; VARIANTS;

D O I：

10.1016/j.radonc.2012.11.003

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The ability to predict individual risk of radiation-induced normal tissue complications is a long sought goal in radiobiology. The last decade saw increasing interest in identifying associations between single nucleotide polymorphisms (SNPs) and normal tissue complication risk. Nevertheless, it remains controversial whether SNPs will be useful predictors of normal tissue radiosensitivity. This paper provides a summary of a scientific debate held at the 31st ESTRO conference in which four scientists argued in favor or against the motion that SNPs will be useful predictors of normal tissue radiosensitivity in the future. (C) 2012 Elsevier Ireland Ltd. All rights reserved. Radiotherapy and Oncology 105 (2012) 283-288

引用

页码：283 / 288

页数：6

共 55 条

[11] Normal tissue reactions to radiotherapy: towards tailoring treatment dose by genotype [J].

Barnett, Gillian C. ;

West, Catherine M. L. ;

Dunning, Alison M. ;

Elliott, Rebecca M. ;

Coles, Charlotte E. ;

Pharoah, Paul D. P. ;

Burnet, Neil G. .

NATURE REVIEWS CANCER, 2009, 9 (02) :134-142

[12] Radiotherapy plus cetuximab for locoregionally advanced head and neck cancer: 5-year survival data from a phase 3 randomised trial, and relation between cetuximab-induced rash and survival [J].

Bonner, James A. ;

Harari, Paul M. ;

Giralt, Jordi ;

Cohen, Roger B. ;

Jones, Christopher U. ;

Sur, Ranjan K. ;

Raben, David ;

Baselga, Jose ;

Spencer, Sharon A. ;

Zhu, Junming ;

Youssoufian, Hagop ;

Rowinsky, Eric K. ;

Ang, K. Kian .

LANCET ONCOLOGY, 2010, 11 (01) :21-28

[13] PREDICTION OF NORMAL-TISSUE TOLERANCE TO RADIOTHERAPY FROM INVITRO CELLULAR RADIATION SENSITIVITY [J].

BURNET, NG ;

NYMAN, J ;

TURESSON, I ;

WURM, R ;

YARNOLD, JR ;

PEACOCK, JH .

LANCET, 1992, 339 (8809) :1570-1571

[14] Carbamazepine-Induced Toxic Effects and HLA-B*1502 Screening in Taiwan [J].

Chen, Pei ;

Lin, Juei-Jueng ;

Lu, Chin-Song ;

Ong, Cheung-Ter ;

Hsieh, Peiyuan F. ;

Yang, Chih-Chao ;

Tai, Chih-Ta ;

Wu, Shey-Lin ;

Lu, Cheng-Hsien ;

Hsu, Yung-Chu ;

Yu, Hsiang-Yu ;

Ro, Long-Sun ;

Lu, Chung-Ta ;

Chu, Chun-Che ;

Tsai, Jing-Jane ;

Su, Yu-Hsiang ;

Lan, Sheng-Hsing ;

Sung, Sheng-Feng ;

Lin, Shu-Yi ;

Chuang, Hui-Ping ;

Huang, Li-Chen ;

Chen, Ying-Ju ;

Tsai, Pei-Joung ;

Liao, Hung-Ting ;

Lin, Yu-Hsuan ;

Chen, Chien-Hsiun ;

Chung, Wen-Hung ;

Hung, Shuen-Iu ;

Wu, Jer-Yuarn ;

Chang, Chi-Feng ;

Chen, Luke ;

Chen, Yuan-Tsong ;

Shen, Chen-Yang .

NEW ENGLAND JOURNAL OF MEDICINE, 2011, 364 (12) :1126-1133

[15] Residual DNA and chromosomal damage in ex vivo irradiated blood lymphocytes correlated with late normal tissue response to breast radiotherapy [J].

Chua, Melvin Lee Kiang ;

Somaiah, Navita ;

A'Hern, Roger ;

Davies, Sue ;

Gothard, Lone ;

Yarnold, John ;

Rothkamm, Kai .

RADIOTHERAPY AND ONCOLOGY, 2011, 99 (03) :362-366

[16] Uncovering the roles of rare variants in common disease through whole-genome sequencing [J].

Cirulli, Elizabeth T. ;

Goldstein, David B. .

NATURE REVIEWS GENETICS, 2010, 11 (06) :415-425

[17] Needles in stacks of needles: finding disease-causal variants in a wealth of genomic data [J].

Cooper, Gregory M. ;

Shendure, Jay .

NATURE REVIEWS GENETICS, 2011, 12 (09) :628-640

[18]

Dayes I, 2012, Clin Oncol (R Coll Radiol), V24, P488, DOI 10.1016/j.clon.2012.05.003

[19] First report on the patient database for the identification of the genetic pathways involved in patients over-reacting to radiotherapy: GENEPI-II [J].

De Ruysscher, Dirk ;

Severin, Diane ;

Barnes, Elizabeth ;

Baumann, Michael ;

Bristow, Rob ;

Gregoire, Vincent ;

Hoelscher, Tobias ;

Veninga, Theo ;

Polanski, Andrzej ;

van Veen, Evert-Ben ;

Verfaillie, Christine ;

Heeren, Germaine ;

Damaraju, Sambasivarao ;

Just, Uwe ;

Haustermans, Karin .

RADIOTHERAPY AND ONCOLOGY, 2010, 97 (01) :36-39

[20] Why recent studies relating normal tissue response to individual radiosensitivity might have failed and how new studies should be performed [J].

Dikomey, E ;

Borgmann, K ;

Peacock, J ;

Jung, H .

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2003, 56 (04) :1194-1200

← 1 2 3 4 5 6 →