A IncRNA Perspective into (Re)Building the Heart

被引：30
作者：
Frank, Stefan [1 ,2 ,3 ]
Aguirre, Aitor [4 ]
Hescheler, Juergen [2 ]
Kurian, Leo [1 ,2 ,3 ]
机构：
[1] Univ Cologne, Cologne Excellence Cluster Cellular Stress Respon, Cologne, Germany
[2] Univ Cologne, Inst Neurophysiol, Cologne, Germany
[3] Univ Cologne, Ctr Mol Med CMMC, Cologne, Germany
[4] Univ Calif San Diego, Dept Med, Div Cardiovasc Med, La Jolla, CA 92093 USA
来源：
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY | 2016年 / 4卷
关键词：
long non-coding RNAs; embryonic development; homeostasis; cardiac development; cardiac regeneration; cell-fate commitment; LONG NONCODING RNA; LOCKED NUCLEIC-ACIDS; MESSENGER-RNA; CARDIAC-HYPERTROPHY; MAMMALIAN HEART; GENE-THERAPY; ANTISENSE; CELLS; OLIGONUCLEOTIDES; DIFFERENTIATION;
D O I：
10.3389/fcell.2016.00128
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Our conception of the human genome, long focused on the 2% that codes for proteins, has profoundly changed since its first draft assembly in 2001. Since then, an unanticipatedly expansive functionality and convolution has been attributed to the majority of the genome that is transcribed in a cell-type/context-specific manner into transcripts with no apparent protein coding ability. While the majority of these transcripts, currently annotated as long non coding RNAs (IncRNAs), are functionally uncharacterized, their prominent role in embryonic development and tissue homeostasis, especially in the context of the heart, is emerging. In this review, we summarize and discuss the latest advances in understanding the relevance of IncRNAs in (re)building the heart.
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页数：11
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