Multimodal Quantitative Magnetic Resonance Imaging of Thalamic Development and Aging across the Human Lifespan: Implications to Neurodegeneration in Multiple Sclerosis
DEEP GRAY-MATTER;
HUMAN BRAIN;
THEORETICAL-ANALYSIS;
CORTICAL ATROPHY;
RELAXATION-TIME;
CEREBRAL-CORTEX;
NERVOUS-SYSTEM;
LESION LOAD;
DIFFUSION;
MRI;
D O I:
10.1523/JNEUROSCI.4184-11.2011
中图分类号:
Q189 [神经科学];
学科分类号:
071006 ;
摘要:
The human brain thalami play essential roles in integrating cognitive, sensory, and motor functions. In multiple sclerosis (MS), quantitative magnetic resonance imaging (qMRI) measurements of the thalami provide important biomarkers of disease progression, but late development and aging confound the interpretation of data collected from patients over a wide age range. Thalamic tissue volume loss due to natural aging and its interplay with lesion-driven pathology has not been investigated previously. In this work, we used standardized thalamic volumetry combined with diffusion tensor imaging, T2 relaxometry, and lesion mapping on large cohorts of controls (N = 255, age range = 6.2-69.1 years) and MS patients (N = 109, age range = 20.8-68.5 years) to demonstrate early age- and lesion-independent thalamic neurodegeneration.
机构:
UCL, Inst Neurol, NMR Res Unit, Dept Neuroinflammat, London WC1N 3BG, EnglandUCL, Inst Neurol, NMR Res Unit, Dept Neuroinflammat, London WC1N 3BG, England
Chard, Declan
Miller, David
论文数: 0引用数: 0
h-index: 0
机构:
UCL, Inst Neurol, NMR Res Unit, Dept Neuroinflammat, London WC1N 3BG, EnglandUCL, Inst Neurol, NMR Res Unit, Dept Neuroinflammat, London WC1N 3BG, England
机构:
UCL, Inst Neurol, NMR Res Unit, Dept Neuroinflammat, London WC1N 3BG, EnglandUCL, Inst Neurol, NMR Res Unit, Dept Neuroinflammat, London WC1N 3BG, England
Chard, Declan
Miller, David
论文数: 0引用数: 0
h-index: 0
机构:
UCL, Inst Neurol, NMR Res Unit, Dept Neuroinflammat, London WC1N 3BG, EnglandUCL, Inst Neurol, NMR Res Unit, Dept Neuroinflammat, London WC1N 3BG, England