Multimodal Quantitative Magnetic Resonance Imaging of Thalamic Development and Aging across the Human Lifespan: Implications to Neurodegeneration in Multiple Sclerosis

被引:54
作者
Hasan, Khader M. [1 ]
Walimuni, Indika S. [1 ]
Abid, Humaira [1 ]
Frye, Richard E. [2 ]
Ewing-Cobbs, Linda [2 ]
Wolinsky, Jerry S. [3 ]
Narayana, Ponnada A. [1 ]
机构
[1] Univ Texas Hlth Sci Ctr Houston, Dept Diagnost & Intervent Imaging, Houston, TX 77030 USA
[2] Univ Texas Hlth Sci Ctr Houston, Dept Pediat, Houston, TX 77030 USA
[3] Univ Texas Hlth Sci Ctr Houston, Dept Neurol, Houston, TX 77030 USA
基金
美国国家卫生研究院;
关键词
DEEP GRAY-MATTER; HUMAN BRAIN; THEORETICAL-ANALYSIS; CORTICAL ATROPHY; RELAXATION-TIME; CEREBRAL-CORTEX; NERVOUS-SYSTEM; LESION LOAD; DIFFUSION; MRI;
D O I
10.1523/JNEUROSCI.4184-11.2011
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The human brain thalami play essential roles in integrating cognitive, sensory, and motor functions. In multiple sclerosis (MS), quantitative magnetic resonance imaging (qMRI) measurements of the thalami provide important biomarkers of disease progression, but late development and aging confound the interpretation of data collected from patients over a wide age range. Thalamic tissue volume loss due to natural aging and its interplay with lesion-driven pathology has not been investigated previously. In this work, we used standardized thalamic volumetry combined with diffusion tensor imaging, T2 relaxometry, and lesion mapping on large cohorts of controls (N = 255, age range = 6.2-69.1 years) and MS patients (N = 109, age range = 20.8-68.5 years) to demonstrate early age- and lesion-independent thalamic neurodegeneration.
引用
收藏
页码:16826 / 16832
页数:7
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