Platinum and Palladium Complexes with 2,4-Dinitrophenylhydrazine: Synthesis and Cytotoxic Activity

被引：0
作者：
de Souza, Gustavo D. [1 ]
Fernandes, Lucianno E. [1 ]
Rodrigues, Monica A. [1 ]
Silva, Priscila P. [2 ]
Pereira-Maia, Elene C. [2 ]
Guerra, Wendell [1 ]
机构：
[1] Univ Fed Uberlandia, Inst Quim, BR-400902 Uberlandia, MG, Brazil
[2] Univ Fed Minas Gerais, Dept Quim, BR-270901 Belo Horizonte, MG, Brazil
来源：
LATIN AMERICAN JOURNAL OF PHARMACY | 2012年 / 31卷 / 04期
关键词：
Cytotoxic activity; Hydrazones; Metal-based drugs; Platinum complexes; BENZOIC-ACID HYDRAZIDE; COORDINATION-COMPOUNDS; BIOLOGICAL-ACTIVITY; CRYSTAL-STRUCTURE; TETRACYCLINES; CONDUCTIVITY; LIGANDS; AGENTS;
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
New complexes of platinum and palladium were isolated with 2,4-dinitrophenylhydrazine (2A-DNPH). These complexes were characterized and the results shown that the ligand is coordinated to platinum or palladium by the basic nitrogen of NH2 group and have the general structure cis-[M(2,4-DNPH)(2)Cl-2]center dot H2O where M = Pt or Pd. The thermal stability of the complexes was followed in the temperature range 25-850 degrees C. The antitumor activity of the synthesized compounds has been studied and the compound cist[Pt(2A-DNPH)(2)Cl-2], was found to display cytotoxicity (IC50 = 4.6 mu mol/L) against K562 tumoral cell line. This work is the first to describe the cytotoxic activity of complexes containing 2,4-dinitrophenylhydrazine.
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页码：620 / 624
页数：5
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