Cytotoxic clerodane diterpenes from Glossocarya calcicola

被引：20

作者：

Rasikari, HL

Leach, DN

Waterman, PG

Spooner-Hart, RN

Basta, AH

Banbury, LK

Winter, KM

Forster, PI

机构：

[1] So cross Univ, Ctr Phytochem & Pharmacol, Lismore, NSW 2780, Australia

[2] Ctr Hort & Plant Sci, Penrith, NSW 2751, Australia

[3] Brisbane Bot Gardens, Environm Protect Agcy, Queensland Herbarium, Toowong, Qld 4066, Australia

来源：

PHYTOCHEMISTRY | 2005年 / 66卷 / 24期

基金：

澳大利亚研究理事会;

关键词：

Glossocarya calcicola; Lamiaceae; cytotoxicity; insect cell lines; mammalian cell lines; Tetranychus urticae; Plutella xylostella; clerodane diterpenes; calcicolin;

D O I：

10.1016/j.phytochem.2005.09.024

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Three clerodane diterpenes were isolated and identified from leaf extract of Glossocarya calcicola. Compound I has been characterised as (rel)-10 beta H-trans-12 zeta-(2-methylbut-2(E)-enoyl)-1 beta-(isobutanoyl)-6 alpha,13 4-dihydroxyclerodan-4(20),8(18)-dien-7,15-dione-15,16-oxide, to which we have assigned the trivial name calcicolin-A. The other two compounds had the same skeletal structure and C-12 substituent but in compound 2, the C-1 esterifying group becomes 2-methylbut-2(E)-enoic acid and in 3 it becomes 2-methylbutanoic acid. Although anti-insect activity was not observed for G. calcicola, cytotoxicity against insect and human carcinoma cell lines was detected. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：2844 / 2850

页数：7

共 20 条

[1]

Alvarenga SAV, 2001, PHYTOCHEMISTRY, V56, P583, DOI 10.1016/S0031-9422(00)00424-6

[2] INSECT ANTIFEEDANT ACTIVITY OF CLERODANE DITERPENOIDS AGAINST LARVAE OF SPODOPTERA-LITTORALIS (BOISD) (LEPIDOPTERA) [J].