The myogenic regulatory factors, determinants of muscle development, cell identity and regeneration

被引：440

作者：

Hernandez-Hernandez, Manuel ^{[1
,2
,3
]}

Garcia-Gonzalez, Estela G. ^{[1
,2
,3
]}

Brun, Caroline E. ^{[1
,2
,3
]}

Rudnicki, Michael A. ^{[1
,2
,3
]}

机构：

[1] Ottawa Hosp Res Inst, Regenerat Med Program, Sprott Ctr Stem Cell Res, 501 Smyth Rd, Ottawa, ON K1H 8L6, Canada

[2] Univ Ottawa, Dept Med, 451 Smyth Rd, Ottawa, ON K1H 8M5, Canada

[3] Univ Ottawa, Dept Cellular & Mol Med, 451 Smyth Rd, Ottawa, ON K1H 8M5, Canada

来源：

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2017年 / 72卷

基金：

加拿大健康研究院;

关键词：

Myogenic regulatory factors; MyoD; Skeletal muscle; Myogenesis; SKELETAL-MUSCLE; SONIC HEDGEHOG; MYOD FAMILY; TRANSCRIPTIONAL ACTIVATION; DIFFERENTIAL ROLES; PRECURSOR CELLS; SATELLITE CELLS; UP-REGULATION; GENE MYF-5; MICE LEADS;

D O I：

10.1016/j.semcdb.2017.11.010

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The Myogenic Regulatory Factors (MRFs) Myf5, MyoD, myogenin and MRF4 are members of the basic helix-loop-helix family of transcription factors that control the determination and differentiation of skeletal muscle cells during embryogenesis and postnatal myogenesis. The dynamics of their temporal and spatial expression as well as their biochemical properties have allowed the identification of a precise and hierarchical relationship between the four MRFs. This relationship establishes the myogenic lineage as well as the maintenance of the terminal myogenic phenotype. The application of genome-wide technologies has provided important new information as to how the MRFs function to activate muscle gene expression. Application of combined functional genomics technologies along with single cell lineage tracing strategies will allow a deeper understanding of the mechanisms mediating myogenic determination, cell differentiation and muscle regeneration. (C) 2017 The Authors. Published by Elsevier Ltd.

引用

页码：10 / 18

页数：9

共 89 条

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