IgG4-related autoimmune prostatitis: Two cases with or without autoimmune pancreatitis

被引：45

作者：

Nishimori, Isao ^{[1
]}

Kohsaki, Takuhiro ^{[1
]}

Onishi, Saburo ^{[1
]}

Shuin, Taro ^{[2
]}

Kohsaki, Shino ^{[3
]}

Ogawa, Yasuhiro ^{[3
]}

Matsumoto, Manabu ^{[4
]}

Hiroi, Makoto ^{[4
]}

Hamano, Hideaki ^{[5
]}

Kawa, Shigeyuki ^{[6
]}

机构：

[1] Kochi Med Sch, Dept Gastroenterol & Hepatol, Nankoku, Kochi, Japan

[2] Kochi Med Sch, Dept Urol, Nankoku, Kochi, Japan

[3] Kochi Med Sch, Dept Diagnost Radiol & Radiat Oncol, Nankoku, Kochi, Japan

[4] Kochi Med Sch, Lab Diagnost Pathol, Nankoku, Kochi, Japan

[5] Shinshu Univ, Sch Med, Dept Med, Matsumoto, Nagano 390, Japan

[6] Shinshu Univ, Ctr Hlth Safety & Environm Management, Matsumoto, Nagano 390, Japan

来源：

INTERNAL MEDICINE | 2007年 / 46卷 / 24期

关键词：

autoimmune pancreatitis; prostatitis; IgG4-related sclerosing disease; positron emission tomography with [F-18] fluorodeoxyglucose; steroid therapy;

D O I：

10.2169/internalmedicine.46.0452

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Recently, autoimmune pancreatitis (AIP) has been reported with a variety of extra- pancreatic manifestations and infiltration of IgG4-positive cells into the affected organs. We report herein two cases with prostatitis. One was seen in a patient with typical AIP, and the other was observed without any clinical manifestation of AIP. Serum IgG4 levels were elevated in both cases. Histological examination of the prostates showed that parenchymal cells were partially or totally replaced with fibrosis and abundant infiltration of IgG4- positive cells. Significant uptake of [F-18] fluorodeoxyglucose by the prostate was seen in both cases. In the case with AIP, the uptake completely disappeared after steroid therapy. The findings observed in these cases suggest that the pathological mechanism for prostatitis is similar to the mechanism previously implicated in AIP, namely IgG4- related autoimmune prostatitis.

引用

页码：1983 / 1989

页数：7

共 22 条

[1] Diagnosis of autoimmune pancreatitis: The Mayo Clinic experience [J].

Chari, Suresh T. ;

Smyrk, Thomas C. ;

Levy, Michael J. ;

Topazian, Mark D. ;

Takahashi, Naoki ;

Zhang, Lizhi ;

Clain, Jonathan E. ;

Pearson, Randall K. ;

Petersen, Bret T. ;

Vege, Santhi Swaroop ;

Farnell, Michael B. .

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY, 2006, 4 (08) :1010-1016

[2] Autoimmune etiology in chronic prostatitis syndrome: An advance in the understanding of this pathology [J].

Elena Rivero, Virginia ;

Dario Motrich, Ruben ;

Maccioni, Mariana ;

Maria Riera, Clelia .

CRITICAL REVIEWS IN IMMUNOLOGY, 2007, 27 (01) :33-45

[3] Hydronephrosis associated with retroperitoneal fibrosis and sclerosing pancreatitis [J].

Hamano, H ;

Kawa, S ;

Ochi, Y ;

Unno, H ;

Shiba, N ;

Wajiki, M ;

Nakazawa, K ;

Shimojo, H ;

Kiyosawa, K .

LANCET, 2002, 359 (9315) :1403-1404

[4] High serum IgG4 concentrations in patients with sclerosing pancreatitis. [J].

Hamano, H ;

Kawa, S ;

Horiuchi, A ;

Unno, H ;

Furuya, N ;

Akamatsu, T ;

Fukushima, M ;

Nikaido, T ;

Nakayama, K ;

Usuda, N ;

Kiyosawa, K .

NEW ENGLAND JOURNAL OF MEDICINE, 2001, 344 (10) :732-738

[5] Prevalence and distribution of extrapancreatic lesions complicating autoimmune pancreatitis [J].

Hamano, Hideaki ;

Arakura, Norikazu ;

Muraki, Takashi ;

Ozaki, Yayoi ;

Kiyosawa, Kendo ;

Kawa, Shigeyuki .

JOURNAL OF GASTROENTEROLOGY, 2006, 41 (12) :1197-1205

[6] Autoimmune pancreatitis as a new clinical entity - Three cases of autoimmune pancreatitis with effective steroid therapy [J].

Ito, T ;

Nakano, I ;

Koyanagi, S ;

Miyahara, T ;

Migita, Y ;

Ogoshi, K ;

Sakai, H ;

Matsunaga, S ;

Yasuda, O ;

Sumii, T ;

Nawata, H .

DIGESTIVE DISEASES AND SCIENCES, 1997, 42 (07) :1458-1468

[7] A new clinicopathological entity of IgG4-related autoimmune disease [J].

Kamisawa, T ;

Funata, N ;

Hayashi, Y ;

Eishi, Y ;

Koike, M ;

Tsuruta, K ;

Okamoto, A ;

Egawa, N ;

Nakajima, H .

JOURNAL OF GASTROENTEROLOGY, 2003, 38 (10) :982-984

[8] Lymphoplasmacytic sclerosing pancreatitis is a pancreatic lesion of IgG4-related systemic disease [J].

Kamisawa, T ;

Funata, N ;

Hayashi, Y .

AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 2004, 28 (08) :1114-1114

[9] Close relationship between autoimmune pancreatitis and multifocal fibrosclerosis [J].

Kamisawa, T ;

Funata, N ;

Hayashi, Y ;

Tsuruta, K ;

Okamoto, A ;

Amemiya, K ;

Egawa, N ;

Nakajima, H .

GUT, 2003, 52 (05) :683-687

[10] LYMPHOPLASMACYTIC SCLEROSING PANCREATITIS WITH CHOLANGITIS - A VARIANT OF PRIMARY SCLEROSING CHOLANGITIS EXTENSIVELY INVOLVING PANCREAS [J].

KAWAGUCHI, K ;

KOIKE, M ;

TSURUTA, K ;

OKAMOTO, A ;

TABATA, I ;

FUJITA, N .

HUMAN PATHOLOGY, 1991, 22 (04) :387-395

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