Interactions between Myc and Mediators of Inflammation in Chronic Liver Diseases

被引：60
作者：
Liu, Ting [1 ]
Zhou, Yu [2 ]
Ko, Kwang Suk [3 ]
Yang, Heping [4 ]
机构：
[1] Cent S Univ, Xiangya Hosp, Dept Gastroenterol, Changsha 410008, Hunan, Peoples R China
[2] Univ So Calif, Keck Sch Med, GI Liver Ctr, Los Angeles, CA 90033 USA
[3] Ewha Womans Univ, Coll Hlth Sci, Dept Nutr Sci & Food Management, Seoul 150750, South Korea
[4] Cedars Sinai Med Ctr, Dept Med, Div Gastroenterol, Los Angeles, CA 90048 USA
来源：
MEDIATORS OF INFLAMMATION | 2015年 / 2015卷
基金：
中国国家自然科学基金;
关键词：
NF-KAPPA-B; TUMOR-NECROSIS-FACTOR; HEPATIC STELLATE CELLS; C-MYC; FATTY LIVER; SOLUBLE INTERLEUKIN-2-RECEPTOR; TRANSCRIPTION FACTORS; RECEPTOR ANTAGONIST; BILIARY-CIRRHOSIS; IL-8; EXPRESSION;
D O I：
10.1155/2015/276850
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Most chronic liver diseases (CLDs) are characterized by inflammatory processes with aberrant expressions of various pro-and anti-inflammatory mediators in the liver. These mediators are the driving force of many inflammatory liver disorders, which often result in fibrosis, cirrhosis, and liver tumorigenesis. c-Myc is involved in many cellular events such as cell growth, proliferation, and differentiation. c-Myc upregulates IL-8, IL-10, TNF-alpha, and TGF-beta, while IL-1, IL-2, IL-4, TNF-alpha, and TGF-beta promote c-Myc expression. Their interactions play a central role in fibrosis, cirrhosis, and liver cancer. Molecular interference of their interactions offers possible therapeutic potential for CLDs. In this review, current knowledge of the molecular interactions between c-Myc and various well known inflammatory mediators is discussed.
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页数：12
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