Prognostic role of intraparotid lymph node metastasis in primary parotid cancer: Systematic review

被引：29

作者：

Guntinas-Lichius, Orlando ^{[1
,2
,3
]}

Thielker, Jovanna ^{[1
,2
]}

Robbins, K. Thomas ^{[4
]}

Olsen, Kerry D. ^{[5
]}

Shaha, Ashok R. ^{[6
]}

Makitie, Antti A. ^{[7
,8
,9
,10
,11
]}

de Bree, Remco ^{[12
]}

Vander Poorten, Vincent ^{[3
,13
,14
]}

Quer, Miquel ^{[3
,15
]}

Rinaldo, Alessandra ^{[16
]}

Kowalski, Luiz Paulo ^{[17
,18
]}

Rodrigo, Juan Pablo ^{[19
]}

Hamoir, Marc ^{[20
,21
,22
]}

Ferlito, Alfio ^{[23
]}

机构：

[1] Friedrich Schiller Univ, Jena Univ Hosp, Dept Otorhinolaryngol, Jena, Germany

[2] Friedrich Schiller Univ, Jena Univ Hosp, Facial Nerve Ctr, Jena, Germany

[3] Multidisciplinary Salivary Gland Soc, Geneva, Switzerland

[4] Southern Illinois Univ, Dept Otolaryngol Head & Neck Surg, Springfield, IL USA

[5] Mayo Clin, Dept Otorhinolaryngol, Rochester, MN USA

[6] Mem Sloan Kettering Canc Ctr, Head & Neck Serv, 1275 York Ave, New York, NY 10021 USA

[7] Univ Helsinki, Dept Otorhinolaryngol Head & Neck Surg, Helsinki, Finland

[8] Helsinki Univ Hosp, Helsinki, Finland

[9] Univ Helsinki, Res Program Syst Oncol, Fac Med, Helsinki, Finland

[10] Karolinska Inst, Dept Clin Sci Intervent & Technol, Div Ear Nose & Throat Dis, Stockholm, Sweden

[11] Karolinska Hosp, Stockholm, Sweden

[12] Univ Med Ctr Utrecht, Dept Head & Neck Surg Oncol, Utrecht, Netherlands

[13] Univ Hosp Leuven, Otorhinolaryngol Head & Neck Surg, Leuven, Belgium

[14] Dept Oncol, Sect Head & Neck Oncol, Leuven, Belgium

[15] Hosp Santa Creu & Sant Pau, Dept Otolaryngol, Barcelona, Spain

[16] Univ Udine, Sch Med, Udine, Italy

[17] Sao Paulo State Univ, Med Sch, AC Camargo Canc Ctr, Dept Head & Neck Surg & Otorhinolaryngol, Sao Paulo, Brazil

[18] Sao Paulo State Univ, Med Sch, Div Head & Neck Surg, Sao Paulo, Brazil

[19] Univ Oviedo, Inst Univ Oncol Principado Asturias, Hosp Univ Cent Asturias, Serv Otorrinolaringol, Oviedo, Spain

[20] St Luc Univ Hosp, Dept Head Neck Surg, Brussels, Belgium

[21] King Albert II Canc Inst, Brussels, Belgium

[22] Catholic Univ Louvain, Inst Rech Expt & Clin IREC, Brussels, Belgium

[23] Int Head & Neck Sci Grp, Padua, Italy

来源：

HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK | 2021年 / 43卷 / 03期

关键词：

clinical significance; intraparotid lymph node metastasis; nodal metastasis; prevalence; primary parotid cancer; survival; SQUAMOUS-CELL CARCINOMA; MUCOEPIDERMOID CARCINOMA; GLAND; NECK; MANAGEMENT;

D O I：

10.1002/hed.26541

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

Background The prognostic importance of intraparotid lymph node metastasis (P+) in patients with primary parotid gland carcinoma is unclear. Methods Nineteen retrospective and noncomparative cohort studies, published between 1992 and 2020, met the inclusion criteria and included 2202 patients for this systematic review. Results The pooled prevalence of the P in adult patients in the unselected studies was 24.10% (95% confidence interval = 17.95-30.25). The number of P+ lymph nodes per patient was counted in only three studies and ranged from 1 to 11. The 5-year recurrence-free survival rate based on Kaplan-Meier analysis varied from 83% to 88% in P- patients compared to 36% to 54% in P+ patients. The average hazard ratio for tumor recurrence in patients with P+ compared to P- was 2.67 +/- 0.58. Conclusions P+ is an independent negative prognostic factor in primary parotid gland cancer and should be included into the treatment planning.

引用

页码：997 / 1008

页数：12

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