The Interleukin-17 Pathway in Psoriasis and Psoriatic Arthritis: Disease Pathogenesis and Possibilities of Treatment

被引：39

作者：

Frleta, Marina ^{[1
]}

Siebert, Stefan ^{[1
]}

McInnes, Iain B. ^{[1
,2
]}

机构：

[1] Univ Glasgow, Glasgow, Lanark, Scotland

[2] Glasgow Biomed Res Ctr, Coll Med Vet & Life Sci, Inst Infect Immun & Inflammat, Glasgow G12 8QQ, Lanark, Scotland

来源：

CURRENT RHEUMATOLOGY REPORTS | 2014年 / 16卷 / 04期

关键词：

Psoriatic arthritis; Psoriasis; Interleukin-17; IL-17; Interleukin-23; IL-23; Biologic agents; Pathogenesis; Treatment; MONOCLONAL-ANTIBODY; DOUBLE-BLIND; CUTTING EDGE; IL-17; FAMILY; T-CELL; USTEKINUMAB; CYTOKINE; RECEPTOR; SAFETY; SKIN;

D O I：

10.1007/s11926-014-0414-y

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Psoriasis and psoriatic arthritis (PsA) are pathophysiological enigmas among rheumatic diseases. Substantial clinical advances have been made with new therapy targeting different components of the IL-17 and IL-23 pathways. At the same time, an increase in research on the topic has provided new insights into the potential functional effects of treatments on cell types, pathways, and tissues of interest. Here we review our knowledge of all IL-17 family members, their relationships with the IL-23 pathway, and the outcomes of relevant clinical trials in which different strategies for targeting these molecules have been tested in the treatment of moderate to severe psoriasis and PsA.

引用

收藏

页数：8

相关论文

共 62 条

[11]

Fossiez F, 1998, Int Rev Immunol, V16, P541, DOI 10.3109/08830189809043008

[12] Risk of myocardial infarction in patients with psoriasis [J].

Gelfand, Joel M. ;

Neimann, Andrea L. ;

Shin, Daniel B. ;

Wang, Xingmei ;

Margolis, David J. ;

Troxel, Andrea B. .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2006, 296 (14) :1735-1741

[13] Psoriatic arthritis: epidemiology, clinical features, course, and outcome [J].

Gladman, DD ;

Antoni, C ;

Mease, P ;

Clegg, DO ;

Nash, P .

ANNALS OF THE RHEUMATIC DISEASES, 2005, 64 :14-17

[14] Ustekinumab, a human interleukin 12/23 monoclonal antibody, for psoriatic arthritis: randomised, double-blind, placebo-controlled, crossover trial [J].

Gottlieb, Alice ;

Menter, Alan ;

Mendelsohn, Alan ;

Shen, Yaung-Kaung ;

Li, Shu ;

Guzzo, Cynthia ;

Fretzin, Scott ;

Kunynetz, Rod ;

Kavanaugh, Arthur .

LANCET, 2009, 373 (9664) :633-640

[15] Orphan Cytokine Reveals IL-17 Family Secret [J].

Haines, Christopher J. ;

Cua, Daniel J. .

IMMUNITY, 2011, 35 (04) :498-500

[16] High prevalence of psoriatic arthritis in patients with severe psoriasis with suboptimal performance of screening questionnaires [J].

Haroon, Muhammad ;

Kirby, Brian ;

FitzGerald, Oliver .

ANNALS OF THE RHEUMATIC DISEASES, 2013, 72 (05) :736-740

[17] Rates of new-onset psoriasis in patients with rheumatoid arthritis receiving anti-tumour necrosis factor α therapy: results from the British Society for Rheumatology Biologics Register [J].

Harrison, M. J. ;

Dixon, W. G. ;

Watson, K. D. ;

King, Y. ;

Groves, R. ;

Hyrich, K. L. ;

Symmons, D. P. M. .

ANNALS OF THE RHEUMATIC DISEASES, 2009, 68 (02) :209-215

[18] Regulation and function of innate and adaptive interleukin-17-producing cells [J].

Hirota, Keiji ;

Ahlfors, Helena ;

Duarte, Joao H. ;

Stockinger, Brigitta .

EMBO REPORTS, 2012, 13 (02) :113-120

[19] Fate mapping of IL-17-producing T cells in inflammatory responses [J].

Hirota, Keiji ;

Duarte, Joao H. ;

Veldhoen, Marc ;

Hornsby, Eve ;

Li, Ying ;

Cua, Daniel J. ;

Ahlfors, Helena ;

Wilhelm, Christoph ;

Tolaini, Mauro ;

Menzel, Ursula ;

Garefalaki, Anna ;

Potocnik, Alexandre J. ;

Stockinger, Brigitta .

NATURE IMMUNOLOGY, 2011, 12 (03) :255-U95

[20] Effects of AIN457, a Fully Human Antibody to Interleukin-17A, on Psoriasis, Rheumatoid Arthritis, and Uveitis [J].

Hueber, Wolfgang ;

Patel, Dhavalkumar D. ;

Dryja, Thaddeus ;

Wright, Andrew M. ;

Koroleva, Irina ;

Bruin, Gerard ;

Antoni, Christian ;

Draelos, Zoe ;

Gold, Michael H. ;

Durez, Patrick ;

Tak, Paul P. ;

Gomez-Reino, Juan J. ;

Foster, C. Stephen ;

Kim, Rosa Y. ;

Samson, C. Michael ;

Falk, Naomi S. ;

Chu, David S. ;

Callanan, David ;

Quan Dong Nguyen ;

Rose, Kristine ;

Haider, Asifa ;

Di Padova, Franco .

SCIENCE TRANSLATIONAL MEDICINE, 2010, 2 (52)

← 1 2 3 4 5 6 7 →