The Interleukin-17 Pathway in Psoriasis and Psoriatic Arthritis: Disease Pathogenesis and Possibilities of Treatment

被引：39

作者：

Frleta, Marina ^{[1
]}

Siebert, Stefan ^{[1
]}

McInnes, Iain B. ^{[1
,2
]}

机构：

[1] Univ Glasgow, Glasgow, Lanark, Scotland

[2] Glasgow Biomed Res Ctr, Coll Med Vet & Life Sci, Inst Infect Immun & Inflammat, Glasgow G12 8QQ, Lanark, Scotland

来源：

CURRENT RHEUMATOLOGY REPORTS | 2014年 / 16卷 / 04期

关键词：

Psoriatic arthritis; Psoriasis; Interleukin-17; IL-17; Interleukin-23; IL-23; Biologic agents; Pathogenesis; Treatment; MONOCLONAL-ANTIBODY; DOUBLE-BLIND; CUTTING EDGE; IL-17; FAMILY; T-CELL; USTEKINUMAB; CYTOKINE; RECEPTOR; SAFETY; SKIN;

D O I：

10.1007/s11926-014-0414-y

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Psoriasis and psoriatic arthritis (PsA) are pathophysiological enigmas among rheumatic diseases. Substantial clinical advances have been made with new therapy targeting different components of the IL-17 and IL-23 pathways. At the same time, an increase in research on the topic has provided new insights into the potential functional effects of treatments on cell types, pathways, and tissues of interest. Here we review our knowledge of all IL-17 family members, their relationships with the IL-23 pathway, and the outcomes of relevant clinical trials in which different strategies for targeting these molecules have been tested in the treatment of moderate to severe psoriasis and PsA.

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页数：8

相关论文

共 62 条

[1] Increased plasma levels of IL-21 and IL-23 in spondyloarthritis are not associated with clinical and MRI findings [J].

Andersen, Thomas ;

Rasmussen, Tue Kruse ;

Hvid, Malene ;

Holm, Christian Kanstrup ;

Madsen, Karen Jong-Nyo Berenth ;

Jurik, Anne Grethe ;

Hokland, Marianne ;

Stengaard-Pedersen, Kristian ;

Schiottz-Christensen, Berit ;

Deleuran, Bent .

RHEUMATOLOGY INTERNATIONAL, 2012, 32 (02) :387-393

[2] Cutting Edge: IL-23 Receptor GFP Reporter Mice Reveal Distinct Populations of IL-17-Producing Cells [J].

Awasthi, Amit ;

Riol-Blanco, Lorena ;

Jaeger, Anneli ;

Korn, Thomas ;

Pot, Caroline ;

Galileos, George ;

Bettelli, Estelle ;

Kuchroo, Vijay K. ;

Oukka, Mohamed .

JOURNAL OF IMMUNOLOGY, 2009, 182 (10) :5904-5908

[3]

Baeten D., 2013, Lancet

[4] A role for T cell-derived interleukin 22 in psoriatic skin inflammation [J].

Boniface, K. ;

Guignouard, E. ;

Pedretti, N. ;

Garcia, M. ;

Delwail, A. ;

Bernard, F. -X. ;

Nau, F. ;

Guillet, G. ;

Dagregorio, G. ;

Yssel, H. ;

Lecron, J. -C. ;

Morel, F. .

CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2007, 150 (03) :407-415

[5] Sequence variants in the genes for the interleukin-23 receptor (IL23R) and its ligand (IL12B) confer protection against psoriasis [J].

Capon, Francesca ;

Di Meglio, Paola ;

Szaub, Joanna ;

Prescott, Natalie J. ;

Dunster, Christina ;

Baumber, Laura ;

Gutin, Alexander ;

Abkevic, Victor ;

Burden, A. David ;

Lanchbury, Jerry ;

Barker, Jonathan N. ;

Trembath, Richard C. ;

Nestle, Frank O. .

HUMAN GENETICS, 2007, 122 (02) :201-206

[6] A large-scale genetic association study confirms IL12B and leads to the identification of IL23R as psoriasis-risk genes [J].

Cargill, Michele ;

Schrodi, Steven J. ;

Chang, Monica ;

Garcia, Veronica E. ;

Brandon, Rhonda ;

Callis, Kristina P. ;

Matsunami, Nori ;

Ardlie, Kristin G. ;

Civello, Daniel ;

Catanese, Joseph J. ;

Leong, Diane U. ;

Panko, Jackie M. ;

McAllister, Linda B. ;

Hansen, Christopher B. ;

Papenfuss, Jason ;

Prescott, Stephen M. ;

White, Thomas J. ;

Leppert, Mark F. ;

Krueger, Gerald G. ;

Begovich, Ann B. .

AMERICAN JOURNAL OF HUMAN GENETICS, 2007, 80 (02) :273-290

[7]

Coates LC, 2011, J RHEUMATOL, V38, P1496, DOI [10.3899/jrheum.101119, 10.3899/jrheum.101114, 10.3899/jrheum.110278, 10.3899/jrheum.101116]

[8] Cutting Edge: An IL-17F-CreEYFP Reporter Mouse Allows Fate Mapping of Th17 Cells [J].

Croxford, Andrew L. ;

Kurschus, Florian C. ;

Waisman, Ari .

JOURNAL OF IMMUNOLOGY, 2009, 182 (03) :1237-1241

[9] Skin and Peripheral Lymph Node Invariant NKT Cells Are Mainly Retinoic Acid Receptor-Related Orphan Receptor γt+ and Respond Preferentially under Inflammatory Conditions [J].

Doisne, Jean-Marc ;

Becourt, Chantal ;

Amniai, Latiffa ;

Duarte, Nadia ;

Le Luduec, Jean-Benoit ;

Eberl, Gerard ;

Benlagha, Kamel .

JOURNAL OF IMMUNOLOGY, 2009, 183 (03) :2142-2149

[10] Human leucocyte antigen risk alleles for psoriatic arthritis among patients with psoriasis [J].

Eder, Lihi ;

Chandran, Vinod ;

Pellet, Fawnda ;

Shanmugarajah, Sutha ;

Rosen, Cheryl F. ;

Bull, Shelley B. ;

Gladman, Dafna D. .

ANNALS OF THE RHEUMATIC DISEASES, 2012, 71 (01) :50-55

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