Organocatalytic multicomponent synthesis of polysubstituted pyrroles from 1,2-diones, aldehydes and arylamines

被引：39

作者：

Zheng, Yin ^{[1
]}

Wang, Youming ^{[1
]}

Zhou, Zhenghong ^{[1
]}

机构：

[1] Nankai Univ, Inst & State Key Lab Elementoorgan Chem, Collaborat Innovat Ctr Chem Sci & Engn, Tianjin 300071, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2015年 / 51卷 / 93期

基金：

中国国家自然科学基金;

关键词：

INTRAMOLECULAR MICHAEL ADDITION; STEREOCONTROLLED CONSTRUCTION; CYCLIZATION REACTION; CHEMOSELECTIVE SYNTHESIS; EFFICIENT SYNTHESIS; TERMINAL ALKYNES; DOMINO REACTION; DERIVATIVES; MALONONITRILE; CYCLOADDITION;

D O I：

10.1039/c5cc05624a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We have developed an organocatalyzed three-component reaction of 1,2-diones, aldehydes and arylamines, which provides an efficient approach to access polysubstituted pyrroles. In the catalysis of 4-methylbenzenesulfonic acid monohydrate, the reactions of a wide range of 1,2-diones, arylamines and aldehydes took place smoothly to generate the corresponding polysubstituted pyrroles in acceptable to good yields under mild reaction conditions.

引用

页码：16652 / 16655

页数：4

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