Organocatalytic multicomponent synthesis of polysubstituted pyrroles from 1,2-diones, aldehydes and arylamines

被引：39
作者：
Zheng, Yin [1 ]
Wang, Youming [1 ]
Zhou, Zhenghong [1 ]
机构：
[1] Nankai Univ, Inst & State Key Lab Elementoorgan Chem, Collaborat Innovat Ctr Chem Sci & Engn, Tianjin 300071, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2015年 / 51卷 / 93期
基金：
中国国家自然科学基金;
关键词：
INTRAMOLECULAR MICHAEL ADDITION; STEREOCONTROLLED CONSTRUCTION; CYCLIZATION REACTION; CHEMOSELECTIVE SYNTHESIS; EFFICIENT SYNTHESIS; TERMINAL ALKYNES; DOMINO REACTION; DERIVATIVES; MALONONITRILE; CYCLOADDITION;
D O I：
10.1039/c5cc05624a
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
We have developed an organocatalyzed three-component reaction of 1,2-diones, aldehydes and arylamines, which provides an efficient approach to access polysubstituted pyrroles. In the catalysis of 4-methylbenzenesulfonic acid monohydrate, the reactions of a wide range of 1,2-diones, arylamines and aldehydes took place smoothly to generate the corresponding polysubstituted pyrroles in acceptable to good yields under mild reaction conditions.
引用
收藏
页码：16652 / 16655
页数：4
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